摘要
目的探讨妇科千金片治疗盆腔炎的作用机理。方法选用Wistar大鼠,运用子宫内接种混合菌液制造急性盆腔炎模型。随机分为空白组、假手术组、模型组、妇科千金片低、中、高剂量组、妇炎康组及罗红霉素组,治疗后,用ELISA检测血清肿瘤坏死因子-α(TNF-α)、核因子κB(NF-kB)含量。结果与空白组比较,模型组TNF-α、NF-κB的含量明显升高(P<0.05);与模型组比较,妇科千金片低、中、高剂量组、妇炎康组及罗红霉素组的TNF-α、NF-κB含量明显降低(P<0.05)。结论妇科千金片可能是通过调节血清中TNF-α、NF-κB的含量而发挥抗炎作用。
Objective To investigate the mechanism of Gynecologic Qianiin Tablet to treat rats with pelvic inflammatory disease. Methods Female Wistar rats were inoculated mixed bacilli within the uterine to produce acute pelvic inflammatory disease models. Experiment rats were randomly divided into the blank group, the sham-operation group, the model group,the low dosage group,the middle dosage group, the high dosage group, the Fuyankang group, the Roxithromycin group, After 21 days of treatment,the content of Tumor necrosis fctor alpha （TNF alpha）, nuclear factor kB （NF-kB） in serum were testinged by ELISA. Results Compared with the blank group,TNF-a,NF-kB levels of the model group were statistically increased （ P 〈05） ; Compared with the model group,the levels of TNF-a and NF-kB in each treatment groups were statistically decreased （ P 〈05） ; However, all pairwise comparisons between treatment groups had no statistically significant （ P 〉0. 05）. Conclusion Gynecologic Qianjin Tablet may play an anti-inflammatory by decreasing the levels of TNF-a and NF-kB.
出处
《中国中医药现代远程教育》
2014年第7期150-151,共2页
Chinese Medicine Modern Distance Education of China
基金
湖南省高校创新平台开放基金项目[No:10K045]
关键词
妇科千金片
盆腔炎
肿瘤坏死因子-α
核因子ΚB
中医药实验
Gynecologic Qianjin Tablet
Pelvic inflammatory disease
Tumor necrosis factor alpha （TNF alpha）
Nuclear factor KB（NF- kB）
Traditional Chinese medicine experiment
