摘要
目的:探讨糖化血红蛋白(HbA1c)与青年急性心肌梗死的相关性。方法:收集2009年1月至2012年8月于我院诊断急性心梗的青年患者(年龄≤44岁)72例为青年心梗组,选取同期行冠状动脉造影排外冠心病的青年患者79例为青年对照组。研究患者的HbA1c及空腹血糖与青年急性心肌梗死的关系。结果:(1)与青年对照组比较,青年心梗组血浆空腹血糖、HbA1c明显升高(均P<0.05)。(2)Logistic回归分析显示,HbA1c是与青年急性心梗独立相关的危险因素(OR=1.365)。(3)在青年急性心梗组中,单支病变与双支及三支病变的HbA1c水平有显著差异(P<0.05)。结论:HbA1c升高是青年急性心肌梗死的独立危险因素,且与患者的冠脉病变程度密切相关,早期干预糖代谢异常可能为青年心梗的防治提供新思路。
Objective To explore the association between HbAlc and acute myocardial infarction（AMI） in youth. Methods Seventy-two AMI patients （≤44y） diagnosed during the period from January in 2009 to August in 2012 were enrolled and 79 young age-matched adults without coronary artery disease at the same period were enrolled to be control group. The relationship between HbAlc, fasting blood-glucose （FBG） and AMI was explored. Results （ 1 ）Compared with the control group,the plasma FBG and HbA1C value were significantly higher（P〈 0.05） in AMI group. （2）Logistic regression analysis showed that HbAlc is the independent risk factor for AMI in youth. （3）In AMI group, the HbAlc level in single vessel disease had remarkable difference with that in double vessel disease and triple vessel disease（P 〈 0.05）. Conclusions Increasing HbAlc level is the independent risk factor for AMI in youth,and positively correlated with the degree of coronary artery lesions. Primary intervention of glycometabolism abnormality possibly becomes the new opinion for prevention and cure of AMI.
出处
《实用医学杂志》
CAS
北大核心
2014年第9期1411-1414,共4页
The Journal of Practical Medicine
基金
天津市科技计划项目(编号:11ZCGYSY02000)
关键词
心肌梗死
青年
危险因素
糖化血红蛋白
Myocardial infarction
Youth
Risk factor
Glycosylated hemoglobin
