摘要
目的:探讨外周血浆细胞样树突状细胞与急性脑梗死后局部脑免疫炎症反应是否相关。方法:入选急性脑梗死患者(AIS组)62例,健康对照者(Control组)26例,无症状性脑梗死颈动脉狭窄患者(ACI-S组)12例,短暂性脑缺血发作患者(TIA组)14例,采用流式细胞分析检测各组外周血浆细胞样树突状细胞前体(pDCPs)数量。根据脑部磁共振弥散加权成像(DWI)图像评估梗死灶的大小,进一步将AIS组患者分为腔隙性脑梗死组、小梗死组、大梗死组,并比较不同亚组脑梗死患者pDCPs水平;并将AIS组患者pDCPs与NIHSS、CRP做相关分析。结果:AIS组与Control组相比,pDCPs占外周白细胞的比例及绝对数显著下降,差异具有统计学意义(P<0.001);与腔隙性脑梗死组相比,大梗死组患者pDCPs水平显著下降(P=0.001);且NIHSS评分和CRP与pDCPs均呈现明显的负相关。结论 :急性脑梗死患者外周血pDCPs数量减少,可能与募集到梗死的脑组织参与炎症反应有关。
Objective To explore the relation between plasmocytoid dentritic cells （pDCs） and cerebral immune-inflammation reaction following ischemic stroke. Methods Circulating pDCs were measured by flow cytometry in 62 patients with acute ischaemic stroke （AIS）, 26 healthy controls, 12 patients with asymptomatic cerebral infarction stenosis （ACI-S）, and 14 patients with transient ischaemic attack （TIA）. The sizes of infarct lesions were assessed by DWI scanning. AIS group was further divided into lacunar infarction group, small infarction group,and large infarction group according to the infarction area. The correlation between the number of pDCs and NHISS score and CRP level was also analyzed in AIS group. Results The labsolute number of pDCs and the percentage of pDCPs to circulating blood white cells were significantly lower in AIS group than in the healthy control group （P 〈 0.001 ）. As compared with lacunar infarction group, the number of pDCPs decreased significantly in large infarction group. The number of pDCPs was negatively correlated with the levels of CRP and the NIHSS score. Conelutiolas Patients with AIS has a decreased level of circulating pDCs, which may be involved in the gathering of circulating pDCs in the infarcted brain to trigger cerebral immune reaction.
出处
《实用医学杂志》
CAS
北大核心
2014年第9期1394-1397,共4页
The Journal of Practical Medicine
基金
国家自然科学基金资助项目(编号:81271284)
关键词
脑梗死
浆细胞样树突状细胞
免疫炎症
C反应蛋白
NIHSS
Brain infarction
Plasmacytoid dendriticells
Immune-inflammation reaction
C-reactiveprotein
NIHSS
