摘要
目的:探讨骨唾液蛋白(BSP)在乳腺癌组织中的表达状况及与相关因素年龄、淋巴结转移、骨转移、C-erbB-2的关系。方法:应用免疫组化SP法检测60例乳腺癌与60例正常乳腺组织中BSP的表达,以及在乳腺癌组织中的表达与年龄、淋巴结转移、骨转移、C-erbB-2相关因素进行分析。结果:乳腺癌组织中BSP阳性表达率为78.3%,正常乳腺组织中BSP阳性表达率为15.0%,P<0.05有统计学差异。BSP表达与年龄、骨转移相关(P<0.05)。结论:BSP在乳腺癌组织中高表达,与乳腺癌浸润和骨转移密切相关,能指导判断乳腺癌侵袭、转移及预后。
Objective：To study the expression of matrix bone saliva protein （BSP） in breast cancer tissue and the relationship with age,lymph node bone metastasis,C - erbB - 2. Methods：To detect the expression of BSP in 60 ea- ses of breast cancer and 60 eases of normal breast tissue with ilnlnunohistoehelnieal SP, and to analyze the relationship of expression in infiltrating duetal carcinoma of breast tissue with age,lymph node metastasis, bone metastasis, C - erbB - 2. Results：The positive expression rate of BSP in breast cancer tissue was 78.3%. And the positive expression rate of BSP in normal breast tissue was 15.0% （P 〈0.05）. BSP expression was related with age and bone metastasis （P 〈 0.05）. Conclusion：The high expression of BSP was found in breast cancer and the invasion and bone metasta- sis of breast cancer are closely related,and can guide or judge invasion,transfer and prognosis of breast cancer.
出处
《现代肿瘤医学》
CAS
2014年第3期564-566,共3页
Journal of Modern Oncology
关键词
乳腺癌
BSP
转移
预后
breastcancer
BSP
transfer
prognosis
