摘要
目的分析淋巴细胞主动免疫联合丙种球蛋白治疗原因不明性复发性流产(URSA)的临床效果。方法选取URSA患者144例,随机分为两组,均采用丙种球蛋白静脉滴注治疗,观察组再进行淋巴细胞主动免疫治疗,治疗后观察两组患者的临床效果。结果治疗前两组患者CD3+、CD4+、IL-10及NK水平无统计学差异(P>0.05);治疗后两组患者CD3+及IL-10水平均较治疗前升高(P<0.01),观察组升高幅度大于对照组(P<0.01);治疗后两组患者CD4+及NK水平均较治疗前降低(P<0.01),观察组降低幅度大于对照组(P<0.01)。观察组妊娠成功率为87.5%,高于对照组的62.5%(P<0.01)。结论淋巴细胞主动免疫联合丙种球蛋白治疗URSA临床效果满意。
Objective To study the clinical effectiveness of lymphocyte active immunotherapy and intravenous immune globulin in the treatment of patients with unexplained recurrent spontaneous abortion （URSA）. Methods One hundred and forty-four patients with unexplained recurrent spontaneous abortion were analyzed and divided into two group, and both the groups received intravenous immune globulin treatment. The observation group received lymphocyte active immunotherapy treatment on the basis of intravenous immune globulin treatment. Clinical effectiveness was observed after treatment. Results The CD3^＋ , CD4^＋, IL-10 and NK levels of the two groups had no significant difference before treatment（ P 〉0.05）. The CD3^＋ and IL-10 of the two groups were improved after treatment（ P 〈0.01 ） ,and the improvement of observation group was significantly better than that of control group（ P 〈0.01 ）. CD4^＋ and NK levels after treatment were lower than that before treatment（ P 〈0.01 ） ,but the observation group had a bigger drop than the control group（ P 〈0.01 ）. The pregnancy success rate of observation group was 87.5% ,higher than 62.5% of control group（ P 〈0.01 ）. Conclusion Lymphocyte active immunotherapy and intravenous immune globulin in the treatment of patients with URSA is effective.
出处
《白求恩医学杂志》
2014年第2期112-114,共3页
Journal of Bethune Medical Science
关键词
复发性流产
丙种球蛋白
淋巴细胞
主动免疫
Recurrent spontaneous abortion
Immune globulin
Lymphocyte
Active immunization
