摘要
目的:探讨瑞舒伐他汀联合培哚普利对高血压患者低密度脂蛋白胆固醇(LDL-C)/高密度脂蛋白胆固醇(HDL-C)和颈动脉内膜中层厚度(IMT)的影响及二者之间的相关性。方法:入选初诊高血压伴高LDL-C血症患者126例,在给予基础降压治疗基础上随机分为治疗组63例(培哚普利+瑞舒伐他汀治疗)和对照组63例(瑞舒伐他汀治疗)。比较治疗前和治疗3周后血压、LDL-C、HDL-C、LDL-C/HDL-C和IMT变化。结果:治疗后治疗组收缩压、舒张压和平均动脉压均较对照组下降明显(P=0.012,P=0.029,P=0.037)。两组患者治疗前后LDL-C、HDL-C比较均没有统计学差异(P均>0.05)。但治疗组治疗后LDL-C/HDL-C下降较对照组明显(P=0.007),平均IMT和最大IMT均明显小于照组(P=0.001,P<0.001)。治疗前后LDL-C/HDL-C差值与平均IMT差值呈正相关(P<0.001,r=0.742)。结论:瑞舒伐他汀联合培哚普利可以逆转高血压伴高LDL-C血症患者颈动脉内膜斑块,二者联合使用对减少心脑血管疾病的发生有重要意义。
Objective：To investigate the efficacy of rosuvastatin combined with perindopril on LDL-C/HDL-C and carotid intima media thickness （ IMT） in hypertension patients, and the correlation between LDL-C/HDL-C and IMT.Method：A total of 126 high LDL-C patients with newly diagnosed hypertension＆amp;nbsp;were randomized to treatment group （n=63） and control group （n=63） after enrolled.On the basis of rou-tine antihypertensive therapy , treatment group received rosuvastatin treatment with the addition of perindopril and control group received rosuvastatin treatment only .Blood pressure , LDL-C, HDL-C, LDL-C/HDL-C and IMT were collected before and after 3 weeks treatment .Result：Systolic blood pressure （ SBP ） , dystolic blood pressure （ DBP ） , and mean blood pressure in treatment group were lower than that in control group af-ter treatment （P=0.012, P=0.029, P=0.037）.Blood levels of LDL-C and HDL-C were similar between the two groups （ all P＆gt;0.05） .But levels of LDL-C/HDL-C, mean IMT and MAX IMT in treatment group all decreased significantly after treatment compared to control group （ P=0.007, P=0.001, P＆lt;0.001）. Changes of LDL-C/HDL-C was positively correlated with changes of mean IMT （P＆lt;0.001,r=0.742）.Con-clusion：Rosuvastatin combined with perindopril can reverse carotid intima atherosclerosis in hypertension patients with high LDL-C.Both of them are closely correlated with preventing cardiovascular and cerebrovas-cular diseases .
出处
《河北医学》
CAS
2014年第5期744-748,共5页
Hebei Medicine
