期刊文献+

DPP-4抑制剂:不仅仅是一种降糖药

Dipeptidyl peptidase-4 inhibitors:more than an anti-hyperglycemia agent
下载PDF
导出
摘要 二肽基肽酶4(DPP-4)抑制剂是一类新型口服降糖药物,主要通过提高胰高血糖素样肽-1(GLP-1)浓度刺激胰岛素、抑制胰高糖素分泌而控制糖尿病患者血糖,临床应用越来越广泛。除降糖作用之外,DPP-4抑制剂还显现出调节炎症反应、降低心血管危险因素、促进伤口愈合以及改善阿尔茨海默病等降糖外作用。
作者 刘晓丹 李焱
出处 《药品评价》 CAS 2014年第7期26-28,35,共4页 Drug Evaluation
  • 相关文献

参考文献18

  • 1Shah Z, Kampfrath T, Deiuliis JA, et al. Long-term dipeptidyl-peptidase 4 inhibition reduces atherosclerosis and inflammation via effects on monocyte recruitment and chemotaxis[J]. Circulation, 2011, 124(21): 2338-2349. 被引量:1
  • 2Shirakawa J, Fujii H, Ohnuma K, et al. Diet-induced adipose tissue inflammation and liver steatosis are prevented by DPP-4 inhibition in diabetic mice[J]. Diabetes, 2011, 60(4): 1246-1257. 被引量:1
  • 3Satoh-Asahara N, Sasaki Y, Wada H, et al. A dipeptidyl peptidase-4 inhibitor, sitagliptin, exerts anti-inflammatory effects in type 2 diabetic patients[J]. Metabolism, 2013, 62(3): 347-351. 被引量:1
  • 4Matsubara J, Sugiyama S, Sugamura K, et al. A dipeptidyl peptidase-4 inhibitor, des-fluoro-sitagliptin, improves endothelial function and reduces atherosclerotie lesion formation in apolipoprotein E-deficient mice[J]. J Am Coll Cardiol, 2012, 59(3): 265-276. 被引量:1
  • 5Matsubara J, Sugiyama S, Akiyama E, et al. Dipeptidyl peptidase-4 inhibitor, sitagliptin, improves endothelial dysfunction in association with its anti-inflammatory effects in patients with coronary artery disease and uncontrolled diabetes[J]. Circ J, 2013, 77(5): 1337-1344. 被引量:1
  • 6Ta NN, Schuyler CA, Li Y, et al. DPP-4 (CD26) inhibitor alogliptin inhibits atherosclerosis in diabetic apolipoprotein E-deficient mice[J]. J Cardiovasc Pharmacol, 2011, 58(2): 157-166. 被引量:1
  • 7Ervinna N, Mita T, Yasunari E, et al. Anagliptin, a DPP-4 inhibitor, suppresses proliferation of vascular smooth muscles and monocyte inflammatory reaction and attenuates atherosclerosis in male apo E-deficient mice[J1. Endocrinology, 2013, 154(3 ): 1260-1270. 被引量:1
  • 8Patil HR, Al Badarin F J, Al Shami HA, et al. Meta-analysis of effect of dipeptidyl peptidase-4 inhibitors on cardiovascular risk in type 2 diabetes mellitus[J]. Am J Cardiol, 2012, 110(6): 826-833. 被引量:1
  • 9White WB, Cannon CP, Heller SR, et al. Alogliptin after acute coronary syndrome in patients with type 2 diabetes[J]. N Engl J Med, 2013, 369(14): 1327-1335. 被引量:1
  • 10Schurmann C, Linke A, Engelmann-Pilger K, et al. The dipeptidyl peptidase-4 inhibitor linagliptin attenuates inflammation and accelerates epithelialization in wounds of diabetic ob/ob mice[J]. J Pharmacol Exp Ther, 2012, 342(1): 71-80. 被引量:1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部