摘要
目前临床上用到的降糖药物种类众多,作用机制各异。本文依作用机制将降糖药物进行了分类,并对各类药物的作用机制和特点进行了简要介绍。对全球首个上市的胰高血糖素样肽-1(Glucagon-like peptide-1,GLP-1)类似物艾塞那肽进行了重点阐述,包括氨基酸序列、作用机制、药物动力学、上市制剂和在研制剂等。
There are a lot of antidiabetic medications with different mechansims. The mechanism of action and characteristic of various durgs were introduced. Exenatide was the first approved drug of incretin mimetic class, which acts like the naturally occurring hormone glucagon like peptide-1 （GLP-1）. The amino acids sequence, mechanism of action, pharmacokinetic, approved-preparations, research and development of exenatide were reviewed.
出处
《药品评价》
CAS
2014年第6期17-20,29,共5页
Drug Evaluation
