摘要
目的:观察不同黄连剂量的辛开苦降方对初发2型糖尿病(T2DM)KKay小鼠血糖的影响。方法:10周龄雄性初发T2DM KKay小鼠40只随机分为4组:模型组、罗格列酮组、辛开苦降组、辛开苦降倍黄连组,每组10只。正常组选10周龄雄性C57BL/6J小鼠10只。正常组及模型组给予0.5%羧甲基纤维素钠溶液(CMC)灌胃。各组连续灌胃给药4周后取材,测定其空腹血糖(FPG)。结果:与正常组相比,模型组FPG明显升高(P<0.01);与模型组相比,罗格列酮组、辛开苦降倍黄连组FPG明显降低(P<0.01,P<0.05),而辛开苦降组FPG未见显著变化;与辛开苦降组相比,辛开苦降倍黄连组FPG明显降低(P<0.05)。结论:辛开苦降方降低T2DM KKay小鼠血糖的疗效与黄连用量密切相关,基于辛开苦降配伍的黄连降糖作用存在量效关系。
Objective： To observe the effects of Xinkai Kujiang Formula with the different amounts of Coptis on KKay mice with incipient type 2 diabetes mellitus. Methods： 40 male 10-week-old KKay mice with type 2 diabetes mellitus were randomly assigned into the following four groups： the model group, Rosiglitazone group, Xinkai Kujiang group, Xinkai Kujiang Formula with double amount of Coptis group. Ten male C57BL/tJ mice （10 weeks old） served as a non-diabetic control group. The mice in the control and model groups were intragastrically administered with 0.5% sodium carboxymethyl cellulose solution. Blood and tissue samples were collected after 4 weeks of treatment. Fasting plasma glucose （FPG） was detected. Results： Compared with the normal group, the FPG in the model group was apparently increased （P〈0.01）. Compared with the model group, the FPG in the Rosiglitazone group and Xinkai Kujiang Formula with double amount of Coptis group were apparently decreased （P〈0.01, P〈0.05）, while the FPG in the Xinkai Kujiang Formula group did not significantly change. Compared with Xinkai Kujiang Formula group, the FPG in Xinkai Kujiang Formula with double amount of Coptis group were decreased （P〈0.05）. Conclusion： The effects of Xinkai Kujiang Formula which lower the FPG of KKay mice with type 2 diabetes mellitus are closely related to the amount of Coptis. Dose-effect relationship exists in the amount of coptis which lower FPG based on Xinkai Kujiang compatibility.
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2014年第5期1547-1549,共3页
China Journal of Traditional Chinese Medicine and Pharmacy
基金
国家自然科学基金(No.81072735)~~
关键词
辛开苦降方
2型糖尿病
KKay
Jx鼠
黄连
量效关系
Xinkai Kujiang Formula
Type 2 diabetes mellitus
KKay mice
Coptis
Dose-effect relationship
