摘要
目的:初步评价电针治疗严重功能性便秘的有效性,比较电针与假电针的疗效。方法:120例患严重功能性便秘的患者随机分为电针组和假电针组,每组60例。电针组电针双侧天枢、腹结、上巨虚;假电针组安慰针针刺双侧天枢、腹结、上巨虚非穴点。基线评价2周,治疗8周,随访12周。观察治疗8周(同时评价治疗前4周和后4周)和随访12周平均周完全自主排便次数(CSBMs)≥3次比例及与基线相比CSBMs的变化;以及与基线相比,治疗8周平均周自主排便次数(SBMs)、粪便性状和排便困难程度的变化。结果:电针组前4周治疗、后4周治疗、治疗8周及随访12周平均周CSBMs≥3次的比例依次为21.67%、50.00%、31.67%和40.00%;假电针组的比例依次为15.00%、33.33%、25.00%和20.00%。随访12周平均周CSBM≥3次的比例两组比较差异具统计学意义(P<0.05)。与基线相比,两组均可显著增加平均周CSBMs和平均周SBMs,并显著改善粪便性状和排便困难程度(P<0.01)。与假电针组相比,电针组对治疗后4周、治疗8周,随访12周平均周CSBMs及治疗8周平均周SBMs增加更显著(P<0.05,P<0.01);电针组治疗8周平均周粪便性状、排便困难程度优于假电针组(P<0.05),改善程度上两者差异不明显。两组均未见明显不良反应。结论:电针和假电针均可增加严重功能性便秘的完全周自主排便次数和周自主排便次数,并可改善粪便性状和排便困难程度。治疗期后期疗效和随访疗效电针优于假电针。
Objective： To preliminarily investigate the efficacy of electro-acupuncture （EA） for severe functional constipation, and to compare the effects between EA and sham-EA. Methods： A total of 120 patients with severe functional constipation were randomly divided into EA group and sham-EA group, with 60 patients in each group. Patients in EA group were treated with electro-acupuncture in bilateral Tianshu, Fujie, Shangjuxu, while those in sham-EA group were treated by acupuncture in non-points near bilateral Tianshu, Fujie, Shangjuxu. Participants were assessed for 2 weeks, treated for 8 weeks, and followed up for 12 weeks. Primary outcome was the percentage of participants with average CSBMs/week≥〉3 over the first 4-week treatment, the last 4-week treatment, the entire 8-week treatment and 12-week follow-up. The changes compared with baseline in mean value of complete spontaneous bowel movements （CSBMs） per week over the first 4-week treatment, the last 4-week treatment, the entire 8-week treatment, and 12-week follow-up were observed. The changes compared with the baseline in mean number of weekly spontaneous bowel movements （SBMs）, stool character and defecating difficulty were observed over 8-week treatment. Results： The percentage of participants with mean CSBMs/week≥ 3 in EA group was 21.67%, 50.00%, 31.67%, and 40.00% respectively over the first 4-week treatment, the last 4-week treatment, the entire 8-week treatment, and 12- week follow-up; The proportion was 15.00%, 33.33%, 25.00% and 20.00% respectively in sham-EA group. There were statistical significantly differences between the two groups of the proportion over the 12-week follow-up （P〈0.05）. Compared with baseline,the means of CSBMs and SBMs per week both increased in EA and sham-EA groups, and the mean stool character and defecating difficulty per week also both improved in two groups （P〈0.01）. Compared with sham-EA group, EA group demonstrated better effects in increasing the mean CSBMs/week over the last 4-week trea
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2014年第5期1424-1428,共5页
China Journal of Traditional Chinese Medicine and Pharmacy
基金
"十二五"国家科技支撑计划项目(No.2012BAI24B01)~~
关键词
严重功能性便秘
电针
假电针
随机对照
预试验
Severe functional constipation
Electro-acupuncture
Sham-EA
Randomized controlled
Pilot trial
