摘要
上皮间质转化过程与肿瘤的侵袭转移等特性密切相关,在肿瘤发生发展中的研究日益深入。甲状腺乳头状癌中有侵袭性区域,这部分组织黏附分子表达缺失,甲状腺未分化癌中有较多肿瘤相关干细胞特征的细胞。上皮间质转化可能在甲状腺肿瘤进展中发挥重要作用,这也是研究甲状腺未分化肿瘤靶向药物的新方向。
Increasing evidences have demonstrated the roles of epithelial-mesenchymal transition in tumor invasion and metastasis. In the invasive front of papillary thyroid carcinoma, the expressions of adhesion molecules are often lost. In anaplastic thyroid carcinoma, tumor cells showing cancer stem cell ：characteristics have been identified. Epithelial-mesenchymal transition may thus play a key role in the progression of thyroid cancer. Therefore, it provide new insight for the development of targeted drugs for anaplastie thyroid carcinoma.
出处
《中国医学科学院学报》
CAS
CSCD
北大核心
2014年第2期218-222,共5页
Acta Academiae Medicinae Sinicae
关键词
肿瘤
上皮间质转化
侵袭性区域
肿瘤干细胞
tumor
epi＇thelial-mesenchymal transition
invasive front, i cancer stem cell ＇
