摘要
[目的]探讨部分脾动脉栓塞术(PSE)治疗肝硬化门静脉高压症的临床疗效及安全性。[方法]对48例不同原因肝硬化门静脉高压患者行PSE治疗,观察术前及术后1周、1、3、6个月血常规、肝功能、脾脏厚度、脾静脉和门静脉内径、Child-Pugh分级变化及并发症情况。[结果]PSE后患者白细胞和血小板计数均明显升高(P<0.01);术后1个月患者脾静脉和门静脉内径明显缩小(P<0.05,P<0.01),术后6个月脾脏厚度明显缩小(P<0.05);术后患者凝血酶原时间缩短(P<0.01),总胆红素升高(P<0.01),但谷草转氨酶、谷丙转氨酶及ChildPugh分级变化PSE前、后差异无统计学意义(P>0.05);PSE后并发症较多,但未发现严重的并发症。[结论]PSE治疗肝炎肝硬化门静脉高压症合并脾功能亢进安全有效。
[Objective]To investigate the therapeutic effect and security of partial splenic artery emboli- zation （PSE） in patients with liver cirrhosis and portal hypertension. [Methods] Forty-eight cases with liv- er cirrhosis and portal hypertension were treated with PSE. The blood routine test, liver function, the thick- ness of the spleen, splenic vein （SV） and portal vein （PV）diameter, Child-Pugh classification changes and the complications were observed respectively before PSE and 1 week, lmonth, 3 months, 6 months after PSE. [Results]After the operation, the numbers of leucocytes and platelets were significantly increased （P 〈0. 01） ,and the SV and PV diameter more reduced 1 month after PSE and later（P〈0.05,P〈0.01） ,and spleen thickness became much smaller after 6 months（P〈0.05）, Prothrombin time （PT） was significantly shortened and TBil increased （P〈0.01）, but there was no significant difference in AST, ALT and Child- Pugh grade before and after operation（P〉0.05）. Many complications happened after PSE, but no serious complications were found. [Conclusion]PSE is safe and effective for curing cirrhosis together with hyper- splenism and portal hypertension.
出处
《临床消化病杂志》
2014年第1期33-36,共4页
Chinese Journal of Clinical Gastroenterology
