期刊文献+

运动防治肥胖的分子机制

The molecular mechanisms of exercise exerting prophylaxis and treatment of obesity
下载PDF
导出
摘要 运动能防治肥胖等代谢性疾病早已为人们熟知,但其机制一直不甚明了。直到irisin这种新的蛋白类激素被发现,方揭开运动-PGC-1α-FNDC5/irisin-UCP1通路是运动防治肥胖等代谢性疾病的分子机制。 The mechanisms underlying the therapeutic effects of exercise on obesity has remained unknown until irisin,a novel protein-hormone,was identified.Exercise-PGC-1α-FNDC5/irisin-UCP1 pathway is the molecular mechanism to prevent and treat obesity.
作者 彭茜 安振梅
出处 《基础医学与临床》 CSCD 北大核心 2014年第5期715-718,共4页 Basic and Clinical Medicine
关键词 运动 PGC-1Α FNDC5 irisin UCP1 exercise PGC-1α FNDC5/irisin UCP1
  • 相关文献

参考文献16

  • 1Pedersen BK,Febbraio MA.Muscles,exercise and obesity:Skeletal muscle as a secretory organ[J].Nat Rev Endocrinol,2012,8:457-465. 被引量:1
  • 2Bostr(o)m P,Wu J,Jeddrychowski MP,et al.A PGC-1α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis[J].Nature,2012,481:463-468. 被引量:1
  • 3Monsalve M,Wu ZD,Adelmant G,et al.Direct coupling of transcription and mRNA processing through the thermogenic coactivator PGC-1[J].Mol Cell,2000,6:307-316. 被引量:1
  • 4Vitor AL,Benton CR,Yan Z,et al.PGC-1α regulation by exercise training and its influences on muscle function and insulin sensitivity[J].Am J Physiol Endocr Metab,2010,299:145-161. 被引量:1
  • 5Seale P,Bjork B,Yang W,et al.PRDMl6 controls a brown fat/skeletal muscle switch[J].Nature,2008,454:961-967. 被引量:1
  • 6Fernandez-Marcos PJ,Auwerx J.Regulation of PGC-1 α,a nodal regulator of mitochondrial biogenesis[J].Am J Clin Nutr,2011,93:884S-890S. 被引量:1
  • 7Egan B,Carson BP,Garcia-Roves,et al.Exercise intensity-dependent regulation of peroxisome proliferator-activated receptor coactivator-1 mRNA abundance is associated with differential activation of upstream signaling kinases in human skeletal muscle[J].J Physiol,2010,588:1779-1790. 被引量:1
  • 8Timmons JA,Baar K,Davidsen PK,et al.Is irisin a human exercise gene?[J].Nature,2012,488:9-11. 被引量:1
  • 9Virtanen KA,Lidell ME,Orava J,et al.Functional brown adipose tissue in healthy adults[J].N Engl J Med,2009,360:1518-1525. 被引量:1
  • 10Van Marken Lichtenbel WD,Vanhommerig JW,Smulders NM,et al.Cold-activated brown adipose tissue in healthy men[J].N Engl J Med,2009,360:1500-1508. 被引量:1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部