摘要
凝血酶原复合物（PCC）的制备工艺目前国内外基本相同，都是以新鲜冰冻血浆（FFP）为起始原料，经DEAEA-50凝胶批式吸附（1次或者2次），超滤配制，冷冻干燥，并在制备过程中采用有机溶剂／去污剂（Solvent／Detergent，S／D）灭活脂包膜病毒（如HIV等），
Prothrombin complex concentrate （PCC）, rich in vitamin K-dependent coagulation factors, is primarily used for treatment of bleeding caused by congenital or acquired vitamin K-dependent coagulation factor deficiency. Its main indications include Hemophilia B, liver disease and reversal of oral anticoagulation. The advantages of PCC are fast, efficient, safe, which is incomparable by fresh frozen plasma. Although there is a certain risk of thrombotic complications, it can be reduced to the lowest if cautious administration according to the clinical representation of patients. Therefore, PCC is effective and safe in supplying vitamin K-dependent coagulations factors, curing liver disease and reversal of oral anticoagulation.
出处
《临床血液学杂志（输血与检验）》
CAS
2014年第2期352-355,共4页
Journal of Clinical Hematology(Blood Transfusion & Laboratory Medicine)
关键词
凝血酶原复合物
肝病
口服抗凝逆转
血栓
prothrombin complex concentrate
liver disease
oral anticoagulation reversal
thrombosis
