摘要
目的 探讨灼口综合征患者治疗前后血清IL-2、6和TNF-α水平的变化及疗效.方法 选择灼口综合征患者50例（病例组）予以氯硝西泮片2 mg,1次/d;氟西汀胶囊20 mg,1次/d,连用4周.观察并比较治疗前和治疗4周后血浆细胞因子IL-2、6和TNF-α水平的变化,并进行临床疗效观察.另选择同期在体检中心体检的健康者30例作为对照组.结果 治疗前病例组血清IL-2、6和TNF-α水平明显高于对照组（=4.31、2.97、3.84,均P＜0.01）.治疗4周后,患者血清IL-2、6和TNF-α水平均较治疗前明显下降（t=2.88、2.34、3.21,P＜0.05或P＜0.01）.治疗4周后病例组治愈6例、显效14例和有效24例,临床总有效率高达88.0％ （44/50）.结论 灼口综合征患者存在血清IL-2、6和TNF-α水平的异常升高,可作为灼口综合征早期诊断的敏感血清学指标.血清IL-2、6和TNF-α水平的变化可作为灼口综合征患者治疗疗效随访和预后观察的指标.
Objective To discuss changes and curative effect of serum interleukin-2 and 6 and tumor necrosis factor-α （TNF-α） of burning mouth syndrome （BMS） patients before and after medical treatment.Methods 50 cases of BMS patients were selected as case group,and who were given Clonazepam tablets （2mg） and Fluoxetine capsules （20 mg） one time daily for 4 weeks.Observe and compare the changes of serum IL-2 and 6,and TNF-αof patients in two groups before and after 4 weeks＆#39; medical treatment,and proceeded with the clinical curative effect observation.Moreover,30 cases of healthy subjects who just took the physical examination in medical examination center（MEC） at that moment was the control group.Results The serum IL-2 and IL-6,and TNF-αlevels of patients in case group before medical treatment was obviously higher than those in control group （t =4.31,2.97,3.84,all P 〈0.01）.After 4 weeks＆#39; medical treatment,serum IL-2 and IL-6,and TNF-αlevels of patients had obviously declined than before （t =2.88,2.34,3.21,P 〈 0.05 or P 〈 0.01）.After 4 weeks＆#39; medical treatment,there were 6 cured cases,14 cases with significant effect,and 24 cases with curative effect,and the total clinical efficiency reaches 88.0% （44/50）.Conclusion BMS patients have abnormal elevation of serum IL-2 and 6,and TNF-α,which may be the sensitive serological indicators of the early diagnosis of BMS.The changes of serum IL-2 and IL-6,and TNF-α levels may be the index of follow-up curative effect and prognosis observation.
出处
《中国基层医药》
CAS
2014年第8期1145-1147,共3页
Chinese Journal of Primary Medicine and Pharmacy
