摘要
目的对大连市金州区37 846例新生儿苯丙酮尿症(PKU)和先天性甲状腺功能减低症(CH)两病筛查进行回顾性分析,探讨新生儿两病筛查率和新生儿两病患病率。方法将2003至2012年大连市金州区新生儿疾病筛查资料进行收集整理分析,总结10年间两病筛查率和患病率的变化趋势。结果 2003至2012年金州区新生儿疾病筛查率为98.7%,高于大连市平均水平的95.6%,经比较差异有统计学意义(x^2=795.263,P<0.01);筛查率呈总体上升趋势(趋势x^2=227.790,P<0.01)。先天性甲状腺功能减低症的发病率为0.42‰(1/2 365),略高于大连市平均水平0.41‰(1/2 451);苯丙酮尿症发病率为0.13‰(1/7 569),略低于大连市平均水平0.15‰(1/6 491),经比较差异均无统计学意义(均P>0.05)。结论大连市金州区新生儿疾病筛查率呈较高水平,CH与PKU患病率均接近大连市的平均水平。两病筛查使CH和PKU患儿得到了早确诊、早治疗,避免了体格和智力障碍,提高了全区儿童的生存质量。
Objective To retrospectively analyze the district-wide screening for phenylketonuria （PKU） and congenital hypothyroidism （CH） among 37 846 newborns in Dalian Jinzhou District and explore the screening rate and prevalence of these two diseases. Methods The neonatal screening analysis data from 2003 to 2012 were collected and analyzed to summarize the changes of screening rate and prevalence rate in 10 years. Results The neonatal disease screening rate in Jinzhou District was 98.7% , which was higher than the average rate in Dalian （95.6%）. The difference was significant （X2 =795. 263, P 〈0.01 ）. Screening rate had an overall upward trend （X2 = 227. 790,P 〈0.01 ）. The incidence of CH was 0.42 per thousand （1/2 365）, which was slightly higher than the average level in Dalian （0.41‰, 1/2 451 ）. The incidence of PKU was 0.13 per thousand （ 1/7 569） , which was slightly lower than the average level in Dalian （0.15 ‰, 1/6 491 ）. The differences were not significant （both P 〉 0.05 ）. Conclusion Neonatal disease screening rate in Jinzhou District is relatively high, and the prevalence of CH and PKU is close to average level of Dalian. Screening of these two diseases ensure early diagnosis and early treatment, which helps to avoid physical and mental disability and improve the life quality of children in whole district.
出处
《中国妇幼健康研究》
2014年第2期330-332,共3页
Chinese Journal of Woman and Child Health Research
关键词
新生儿疾病
先天性甲状腺功能减低症
苯丙酮尿症
筛查率
患病率
neonatal diseases
congenital hypothyroidism （CH）
phenylketonuria （PKU）
screening rate
prevalence rate
