摘要
目的:评价华蟾素注射液对原发性肝癌患者血清前白蛋白(prealbumin,PA)及血管内皮生长因子(vascular endothelial growth factor,VEGF)水平的影响。方法:90例肝癌患者,随机分成观察组和对照组。两组肝癌患者均采用肝动脉栓塞化疗(transcatheter hepatic arterial chemoembolization,TACE),同时对照组应用西药护肝及增加能量药物,而观察组在对照组用药方式基础上,加用华蟾素注射液治疗。结果:TACE治疗后30 d,观察组总有效率64.44%高于对照组42.22%,差异有统计学意义(P<0.05)。TACE治疗后5 d,两组肝癌患者PA水平均显著低于治疗前,差异有统计学意义(P<0.01)。TACE治疗后30 d,观察组PA水平(2.45±0.75)mmol·L-1高于对照组PA水平(2.14±0.64)mmol·L-1,差异有统计学意义(P<0.05)。TACE治疗后30 d,观察组PA水平与治疗前比较,差异无统计学意义(P>0.05)。TACE治疗后5d、30d,两组VEGF水平均低于治疗前,差异有统计学意义(P<0.01)。TACE治疗后30 d,观察组VEGF水平(167.2±37.2)pg·mL-1低于对照组VEGF水平(246.5±39.5)pg·mL-1,差异有统计学意义(P<0.01)。结论:华蟾素注射液联合TACT术治疗肝癌的疗效可靠,可明显改善患者的预后。华蟾素注射液能有效地提高TACE术后肝癌患者的血清PA水平,促进肝功能恢复。华蟾素注射液能有效抑制TACE术后肝癌患者的血清VEGF水平。
Objective： To evaluate the effects of Cinobufacini Injection intervening the serum prealbumin （ PA ） and vascular endothelial growth factor （VEGF） levels in patients with primary liver cancer. Method：90 cases of liver cancer patients were randomly divided into observation group and control group. Two groups＇ patients with hepatoeeUular carci- noma were treated with transcatheter hepatic arterial chemoembolization （TACE）, at the same time, the control group add- ed liver protective drugs and energy - increasing drug of Western medicine. The observation group combined with Cinobu- fotalin Injection. Results ： After treatment of TACE for 30 d, the total effective rate of observation group was 64.44% and higher than that of the control group （42.22%）, and the difference was statistically significant （ P 〈 0. 05 ）. After treat- ment of TACE for 5 d, PA levels of two groups were significantly lower than that before treatment, and the difference was statistically significant （P 〈 0.01 ）. After treatment of TACE for 30 d, the observation group＇ s PA level was （2.45 ± 0. 75） mmol· L-1 and higher than that of the control group （2.14 ±0.64） mmol· L-1 ,and the difference was statisti- cally significant （P 〈 0.05 ）. After treatment of TACE for 30 d, the observation group ‘ s PA level had no significant difference compared with that before treatment （ P 〉 0. 05 ）. After TACE treatment for 5 d, 30 d, VEGF levels of two groups were lower than those before treatment, and the difference was statistically significant （P 〈 0. 01 ）. After treatment of TACE for 30 d, VEGF level of the observation group was （ 167.2 ± 37.2） pg · mL - 1 and lower than that of the control group （ 246.5 ± 39.5 ） pg · mL - 1 , and the difference was statistically significant （ P 〈 0.01 ）. Conclusion ：The therapeutic effect of Cinobufacini Injection combined with TACT in treatment of liver cancer is reliable. Cinobufacini Injection can significantly improve the prognosi
出处
《中华中医药学刊》
CAS
2014年第5期1086-1088,共3页
Chinese Archives of Traditional Chinese Medicine
基金
浙江省医药卫生平台骨干人才计划项目(2013RCB017)
关键词
华蟾素注射液
原发性肝癌
肝动脉栓塞化疗
血清
前白蛋白
血管内皮生长因子
Cinobufacini Injection
primary hepatocellular carcinoma
transcatheter hepatic arterial chemoemboliza-tion
serum
prealbumin
vascular endothelial growth factor
