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纳米梯度可降解输尿管支架的制备及体外降解性能研究 被引量:8

Preparation of polycaprolactone/poly (lactic acid-glycolic acid) biodegradable nano-structure ureteral stent and its degradation assay in vitro
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摘要 目的 探讨聚己内酯/聚乳酸-羟基乙酸(PCL/PLGA)梯度可降解输尿管支架的制备及体外降解性能. 方法 2010年12月至2012年9月采用电纺丝法将质量比为5%、10%、15%、20%、25%、30%的PCL/PLGA制备成梯度可降解输尿管支架,采用扫描电镜观察支架管的微观结构.Instron拉伸仪进行支架的拉伸检测,通过第7、14、21、28、35、42、49、56天时在人体尿液中的降解情况评价5%、15%、25% PCL/PLGA支架的降解性能. 结果 制备的支架呈白色,长15 ~ 20 cm,内径约1.5 mm,外径约2.0 mm.电镜扫描见支架由纳米级纤维构成,具有多孔状结构.拉伸实验结果显示支架管的断裂强度随着PCL比例的增加而增强,其中浓度为5% PCL/PLGA的断裂强度最低,但仍满足可降解支架对材料的力学性能要求.体外降解实验显示3种不同质量比PCL/PLGA支架管的降解曲线均近似直线,其中5%支架降解至第28天时崩解成1~3 mm的小块,15%支架第42天时崩解成小块,而25%支架降解至第56天时崩解. 结论 以PCL/PLGA为原料、采用电纺丝技术制备的输尿管支架具有较好的力学性能及体外降解性能,可满足可降解输尿管支架的需求. Objective To investigate the preparation of a polycaprolactone (PCL)/poly (lactic acid-glycolic acid) (PLGA) degradable ureteral stent and its degradation ability in vitro.Methods From December 2010 to September 2012,degradable ureteral stent was fabricated by electrospinning,using different concentration of PCL/PLGA (5%,10%,15%,20%,25%,30%).The structure of stent was scanned by electron microscopy (SEM).The Instron system was used to test the mechanical property of those stents.The PCL/PLGA stents of different concentration (5%,15%,25%) were immerged into the urine to assess their degradable ability 7,14,21,28,35,42,49,56 days later.Results The inner diameter of the white tubular scaffold was 1.5 mm and the outer diameter was 2.0 mm.The SEM results showed that the scaffold had been made by nanofiber with the structure of multi-porous.The tension test showed that the mechanical property was enhanced with the increasing in the proportion of the PCL.The lowest stress at break was found in 5% PCL/PLGA stent,while it was still sufficient for the mechanical criteria of degradable biomaterial.The degradation curves of different ratio of PCL/PLGA stent were close to a straight line.The 5% PCL/PLGA stent collapsed into pieces within 28 d.The 15% and 25% PCL/PLGA collapsed within 42 d and 56 d,respectively.Conclusion The PCL/PLGA biodegradable ureteral stent has a good mechanical property and the degradation time can fully meet the demand of a ureteral stent.
出处 《中华泌尿外科杂志》 CAS CSCD 北大核心 2014年第4期293-296,共4页 Chinese Journal of Urology
基金 国家自然科学基金(50973043)
关键词 聚己内酯 聚乳酸-羟基乙酸 输尿管 支架 可降解 纳米结构 Polycaprolactone / poly(lactic acid-glycolic acid) Ureter Stents Degradable Nanostructures
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