摘要
目的 了解具有早发冠心病家族史的健康子女血清中炎性因子白细胞介素18（IL-18）、细胞间黏附分子1（ICAM-1）及抗炎因子白细胞介素10（IL-10）、脂联素（APN）的水平变化，及其与冠心病发生、发展及遗传的关系。方法 随机选择50例具有早发冠心病家族史的健康子女为观察组，其中父母一方患冠心病者25例（单亲组），父母双方均患冠心病者25例（双亲组）；以父母双方均无冠心病的健康子女25例作为对照组。应用酶联免疫吸附法（ELISA），测定各组血清IL-18、ICAM-1、APN及IL-10的含量。结果 双亲组和单亲组血清ICAM-1和IL-18均高于对照组，IL-10和APN均低于对照组，差异有显著性（F=6.37-12.74,q=2.29-7.46,P〈0.05）；双亲组与单亲组相比，血清ICAM-1和IL-18增高，IL-10和APN降低，差异有显著性（q=2.41-4.24,P〈0.05）。结论 检测具有早发冠心病家族史的健康子女血清中的炎性因子与抗炎因子水平，有利于发现冠心病的高危人群，为冠心病的一级预防提供可靠的依据。
Objective To investigate the changes of serum inflammatory factors interleukin-18 （IL-18）, intercellular adhesion molecule-1 （ICAM-1）, anti-inflammatory factors interleukin-10 （IL-10）, and adiponectin （APN） of healthy offspring with a family history of early-onset coronary heart disease （CHD）, and their roles in the occurrence and development of the illness. Methods Fifty healthy sons and daughters with a family history of CHD were randomly recruited into observation group, of whom,25 with one of the parents had CHD （single-parent group）; 25 with both parents had CHD, （parents group）. Twenty-five healthy individuals whose parents with no CHD were assigned as control group. The serum levels of IL-18, ICAM-1, IL-10 and APN were determined by enzyme linked immunoasorbent assay （ELISA）. Results In the single-parent group and parents group, the serum levels of IL-18 and ICAM-1 were higher than that in the control group; that of IL-10 and APN were lower, the differences were significant （F=6.37-12.74,q=2.29-7.46,P〈0.05）. Serum levels of IL-18 and ICAM-1 were higher in parents group and that of IL-10 and APN were lower, the differences were significant （q=2.41-4.24,P〈0.05）.Conclusion Detecting serum inflammatory factors and anti-inflammatory factors in healthy offspring with a family history of early-onset CHD conduces to discovering high risk population of CHD, which provides a reliable evidence for primary prevention of the condition.
出处
《齐鲁医学杂志》
2014年第2期129-131,共3页
Medical Journal of Qilu
