摘要
目的分析促性腺激素释放激素激动剂(GnRH-a)联合体外受精-胚胎移植(IVF-ET)治疗子宫腺肌病合并不孕患者的临床妊娠结局。方法回顾性分析156例不孕症患者,其中包括56例子宫腺肌病不孕和100例输卵管因素不孕的患者通过GnRH-a和IVF-ET治疗后分析两组的妊娠结局。结果病例组患者的获卵数(11.54±7.35 vs 15.56±7.25)、受精率(68.73%vs 81.43%)、卵裂率(93.24%vs97.79%)、胚胎种植率(41.79%vs 56.96%)、胎儿体重(kg)(2.81±0.80 vs 3.22±0.76)均明显低于对照组,差异有统计学意义(P<0.05)。病例组的自然流产率(25.00%vs10.00%)、早产率(28.57%vs 10.00%)、胎膜早破率(16.67%vs 3.33%)均明显高于对照组,差异有统计学意义(P<0.05)。而低出生体重儿率(28.57%vs 16.67%)、妊娠期高血压率(9.52%vs 7.78%)、妊娠期贫血率(7.14%vs5.56%)、前置胎盘率(4.76%vs 5.56%)之间两组差异无统计学意义(P>0.05)。结论子宫腺肌病患者的IVF-ET不良妊娠结局较输卵管不孕患者明显增多。
Objective To analyze the impact of adenomyosis on outcomes of women achieved pregnancy through combined treatment of GnRH-a and IVF -ET. Methods A retrospective study of 156 infertile women, including 56 patients with infertility due to adenomyosis and 100 patients with tubal factor infertility. All patients obtained pregnancy through IVF -ET. Results Oocytes-retrieved number （11. 54 ± 7. 35 vs 15.56 ± 7. 25）, fertilization rate （68. 73% vs 81. 43% ） , cleavage rate （93.24% vs 97. 79% ） ,implantation rate （41. 79% vs 56.96% ） and birth weight （2. 81 ± 0. 80 vs 3. 22 ± 0. 76） in the adenomyosis group decreased obviously, compared to the tubal factor group （P 〈0. 05）. Rates of spontaneous abortion （25.00% vs 10.00%）, preterm birth （28.57% vs 10.00%）, premature rupture of membranes （16.67% vs 3.33%） increased significantly in the adenomyosis group （P 〈 0.05）. Rates of small-for-gestational-age（SGA） infants （28.57% vs 16.67%）, pregnancy hypertension（9. 52% vs 7.78% ） , pregnancy anemia （7. 14% vs 5. 56% ） , placenta previa （4.76% vs 5. 56% ） between the two groups were not statistically significant （P 〉0. 05）. Conclusion The rates of adverse pregnancy outcome in adenomyosis patients increase significantly, compared to patients with tubal factor infertility.
出处
《安徽医科大学学报》
CAS
北大核心
2014年第4期483-486,共4页
Acta Universitatis Medicinalis Anhui
基金
安徽省自然科学基金(编号:1208085MH161)
