摘要
目的:制备水飞蓟宾脂肪乳并对其体外释放进行考察。方法:在单因素试验的基础上,采用正交试验设计优化水飞蓟宾脂肪乳处方。采用高压均质法制备水飞蓟宾脂肪乳。结果:脂肪乳平均粒径为(74.42±14)nm,粒径分布系数(PDI)为0.106,Zeta电位为(-30.2±2.13)mV,pH为6.48±0.04,包封率(91.45±0.005 2)%,体外12 h内,累积释放原药的90%左右。结论:本试验获得了较理想的水飞蓟宾脂肪乳,其体外释放具有显著的缓释作用。
Objective：To prepare silybin （ SLB） lipid emulsions and evaluate the drug release behavior in vitro. Methods：Silybin lipid emulsions were prepared by high-pressure homogenization method. Under the guidance of single-factor test, the best formula of SLB lipid emulsions was obtained by orthogonal design. Results：The encapsulation efficiency of SLB lipid emulsions prepared by the optimal formula was （91. 45 ± 0. 005 2） % with the particle size of （74. 42 ± 14）nm and PDI of 0. 106, Zeta potential of （ -30. 2 ± 2. 13）mV and pH of （6. 48 ± 0. 04）. The drug release of SLB lipid emulsions was up to 90% within 12 hours. Conclusion：The opti-mized preparation of SLB with sustained-release property is obtained successfully.
出处
《中国药师》
CAS
2014年第4期568-571,共4页
China Pharmacist
关键词
水飞蓟宾
脂肪乳
制备
体外释药
Silybin
Lipid emulsions
Preparation
Release in vitro
