摘要
p2 7kipl定位于染色体 12p13,含 2个外显子。p2 7一方面抑制CDK激活 ,另一方面尚可抑制激活后的cyclin CDK的活性。p2 7不仅在细胞周期增殖调控中起关键作用 ,而且与细胞的分化发育及凋亡也有关系。p2 7蛋白缺失或低表达在消化系恶性肿瘤中是一个较为普遍的现象 。
p27kip1 maps 12p13 and it has two exons. p27 not only inhibits the activation of acyclin dependent kinases, but also surpress the activity of ctivated cyclin CDKs. p27 plays a key role in the regulation of cell cycle progression, and relates to cell differentiation and apoptosis. Loss of p27 protein or lower level of it is prevalent in digestive tumors, and reduction of p27kip1 protein indicates malignant prognosis.
出处
《中国癌症杂志》
CAS
CSCD
2001年第1期81-83,共3页
China Oncology
