摘要
目的 探讨切线时间常数 ( τt)在慢性阻塞性肺疾病 ( COPD,慢阻肺 )和肺心病患者 F- V曲线形状转变中的变化及临床意义。方法 测定了 90例缓解期 COPD患者 (慢支 43例 ,肺气肿 47例 )及 31例合并肺心病患者的 F- V曲线。并在 F- V曲线上测量高、中、低肺容积的切线时间常数 τt75 、τt5 0 、τt2 5 ,与正常人和吸烟者的 τt作对比分析。结果 1正常范围内 F- V曲线形状呈平台型、直线型、凸型和凹型 4种 ,| τt75 | >1s或 <1s,τt2 5 <1s,τt关系呈“青少年式”或“老年式”;2轻、中度异常的 F- V曲线呈凸型 ,| τt75 | <1s,τt2 5 ≈ 1s或 >1s,τt 关系呈“喇叭式”改变 ;3严重异常的 F- V曲线形状呈双曲线型 ,| τt75 | <1s,τt2 5 =4s～ 10 s,τt关系呈“塔式”改变。结论 双曲线型、τt2 5 极度延长和“塔式”改变是判断病情严重性的三大重要标志。该方法简便准确 。
Objective To explore the changes of tang ent time constant(τ t) in the t ransformation of F V curve configuration in COPD and cor pulmonale patients and clinical implicati ons.Methods We determined the F V curves in 90 COPD patients (43 with chronic bronchi tis, 47 with emphysema) and 31 complicated with cor pulmonale; all patients were in the ameli orated period. The τ t at high, mid and low lung volumes, τ t75 , τ t 50 , τ t25 , were me asured on each F V curve. Results ①Normal ranges: F V curve configuration with plateau, linear, convex and concave types;｜τ t75 ｜> ls or<ls; τ t25 <ls; τ t relationship with *adolescent fashion* or *old fashion*. ②Light and moderate abnormality: With convex type; ｜τ t75 ｜< ls; τ t25 ≈ls or>ls; *trumpet fashion* changes. ③Serious abnormality: With hyperboli c type;｜τ t75 ｜<ls; τ t25 =4s^10s; *tower fashion* changes. Conclusion Hyperbolic type, extreme prolongation of τ t25 and *tower fashion* changes can be assigned as 3 important indices to assess the severity of disease. The convenience and correctness of the method may be availa ble for clinical application.
出处
《华西医科大学学报》
CAS
CSCD
北大核心
2001年第1期101-103,共3页
Journal of West China University of Medical Sciences
基金
华西医科大学校基金资助
关键词
流量-容积曲线形状
切线时间常数
肺心病
慢性阻塞性肺疾病
F V curve configuration Tangent time consta nt Chronic obstructive pulmonary disease Convex type Hyperbolic type *Trumpet fashion* change *Tower fashion* change
