摘要
目的 研究血管紧张素转换酶抑制剂 Enalapril对糖尿病的肾病治疗作用机理。方法 以Enalapril治疗实验性糖尿病大鼠 ,并将正常组、糖尿病对照组及治疗组尿蛋白水平及肾组织转化生长因子 β、糖基化终末产物含量进行比较。结果 Enalapril治疗组大鼠肾组织转化生长因子 β及糖基化终末产物含量与糖尿病对照组相比无下降。结论 Enalapril的肾脏保护作用并非通过抑制肾组织转化生长因子
Objective To elucidate the mechanisms of renoprot ective effects of ACEI on diabetic animals and patients. Methods STZ induced diabetic rats were treated with Enalapril and the levels of urine protein, TGF β and AGEs in renal tissue were measured and compared. R esults The results of TGF β quantitation and AGE fluorescence of Enal april treatment group rats were the same as those of diabetic control rats. Conclusion Suppression of TGF β overexpression or AGEs accumulati on was not implicated in the mechanisms of renoprotective effects of ACEI.
出处
《华西医科大学学报》
CAS
CSCD
北大核心
2001年第1期80-82,共3页
Journal of West China University of Medical Sciences
