期刊文献+

Clinical Analysis of the Incidence and the Treatment of Pediatric Cataract Patients with Optic-nerve Maldevelopment

Clinical Analysis of the Incidence and the Treatment of Pediatric Cataract Patients with Optic-nerve Maldevelopment
下载PDF
导出
摘要 Purpose: To interpret the incidence of optic-nerve maldevelopment in postoperative pediatric cataract patients, and evaluate the clinical efficacy of administration of murine nerve growth factor(mNGF) in such patients.Methods: Pattern visual evoked potential(P-VEP) was used to measure the visual pathway function in 28 cases(56 eyes)with bilateral congenital cataract and 13 cases(13 eyes) with unilateral congenital cataract who underwent cataract extraction and intraocular lens implantation surgeries. The results were compared with 25 age-sex-matched healthy children(50eyes). mNGF was administered in 13 cases(23 eyes) who had visual pathway disorder. The efficacy of mNGF injection was observed. P100 latencies, which were used as a main parameter in P-VEP measurement, were analyzed statistically.Results: When compared with normal children, the P100 latency was significantly prolonged in the congenital cataract group(P<0.05). A significant improvement was noted in the visual pathway of subjects treated with mNGF(P<0.05).Conclusion: Compared with normal children, the congenital cataract patients are more vulnerable to optic-nerve maldevelopment. Murine NGF likely plays a protective and nutritive role in the development of optic nerve in cases of optic-nerve maldevelopment followed by congenital cataract surgery. Purpose:To interpret the incidence of optic-nerve maldevel-opment in postoperative pediatric cataract patients, and evalu-ate the clinical efficacy of administration of murine nerve growth factor (mNGF) in such patients. Methods: Pattern visual evoked potential (P-VEP) was used to measure the visual pathway function in 28 cases (56 eyes) with bilateral congenital cataract and 13 cases (13 eyes) with unilateral congenital cataract who underwent cataract extrac-tion and intraocular lens implantation surgeries..The results were compared with 25 age-sex-matched healthy children (50 eyes)..mNGF was administered in 13 cases (23 eyes) who had visual pathway disorder..The efficacy of mNGF injection was observed. P100 latencies, which were used as a main parame-ter in P-VEP measurement, were analyzed statistically. Results:.When compared with normal children, the P100 la-tency was significantly prolonged in the congenital cataract group (P&lt;0.05). A significant improvement was noted in the visual pathway of subjects treated with mNGF (P&lt;0.05). Conclusion: Compared with normal children, the congenital cataract patients are more vulnerable to optic-nerve maldevel-opment. Murine NGF likely plays a protective and nutritive role in the development of optic nerve in cases of optic-nerve maldevelopment followed by congenital cataract surgery.
出处 《Eye Science》 CAS 2014年第1期12-19,共8页 眼科学报(英文版)
基金 National Nature Science Foundation of China(Grand Number:30973276)
关键词 视神经 发育不良 白内障 发病率 患者 临床分析 治疗 神经生长因子 pediatric cataract optic nerve maldevelopment pattern visual evoked potential(P-VEP) murine nerve growthfactor (mNGF)
  • 引文网络
  • 相关文献

参考文献7

二级参考文献115

共引文献43

;
使用帮助 返回顶部