摘要
目的 :探讨扶正化瘀方预防大鼠肝癌形成的机制。方法 :采用二甲基亚硝胺 (DMN)诱发大鼠肝癌 ,观察扶正化瘀方对肝脏病理及肝组织转化生长因子 βⅡ受体 (TGF βⅡR)表达的影响。 结果 :扶正化瘀方对DMN致大鼠肝癌有一定的抑制作用 ,表现为保护肝细胞、抗肝纤维化、提高癌组织周围表达低下的TGF βⅡR水平。 结论 :扶正化瘀的保护肝细胞、抗肝纤维化、提高肝组织TGF βⅡR的表达可能是该方预防肝癌发生的机制之一。
Objective:To explore the mechanism of Fuzhenghuayufang on preventing hepatocarcinoma.Methods:Hepatocarcinoma in rats was induced successfully by DMN and the effects of Fuzheng huayufang on the pathomorphism and TGF βⅡR expressing was observed.Results:Fuzhenghuayufang could inhibit tumor growth in vivo, protect hepatocyte,resist hepatic fibrosis,and striking increase TGF βⅡR expression around tumor tissue.Conclusion:Fuzhenghuayufang can protect hepatocyte,resist hepatic fibrosis,increase TGF βⅡR levels.It may be one of the mechanisms of inhibiting tumor growth in vivo.
出处
《中国中西医结合消化杂志》
CAS
2001年第1期20-22,共3页
Chinese Journal of Integrated Traditional and Western Medicine on Digestion
