摘要
目的：回顾性分析少数民族地区150例地高辛血药浓度结果，为临床安全、合理、有效使用地高辛提供参考。方法：采用电化学发光免疫测定（ECLIA）法对地高辛进行血药浓度检测，查阅被监测患者的病历，建立药历，根据对地高辛监测结果，对影响地高辛血药浓度的因素进行分析。结果：150例中，血药浓度〈0．5ng·ml^-1。的有8例，在有效血药浓度范围0．5～2．0ng·ml^-1的有110例，出现中毒症状5例；血药浓度〉2．0ng·ml^-1的有32例，出现中毒症状24例。不同民族、年龄、性别对地高辛血药浓度和中毒发生率影响无显著性差异，去乙酰毛花苷和肾衰可显著提高地高辛血药浓度和中毒发生率（P〈0．05）。布依族、苗族、水族的地高辛血药浓度和中毒发生率较汉族有降低的趋势，女性地高辛血药浓度有高于男性的趋势。结论：地高辛血药浓度受多种因素影响，包括对医嘱的遵从性、生理N素、病理因素、联合用药等，开展血药浓度检测，是保障疗效，减少和纠正中毒事件发生的必要途径。
OBJECTIVE For clinical safety, reasonable and effective use of digoxin, the plasma concentrations of digoxin in 150 cases of minority area were retrospectively analyzed. METHODS The plasma concentrations of digoxin in 150 cases were tested by electrochemilumineseence immunoassay method （ECLIA）. Combined with the monitoring results of digoxin, the influ- ence factors on plasma concentration of digoxin were analyzed by reviewing medical records of monitored patients and establis- hing the patient medication record. RGSULTS The monitoring results of plasma concentration of digoxin indicated that there were 8 cases their plasma concentrations below 0. 5 ng. ml-1 ; 110 cases between 0. 5 ng. ml-I and 2.0 ng~ ml-1, with poisoning symptoms in 5 cases; 32 cases above 2. 0 ng.ml-~ ,with poisoning symptoms in 24 cases. The analytic results showed that dif- ferent nationality, age and gender had no significant difference in plasma concentration and poisoning rate of digoxin,while desl- anoside and renal failure significantly increased plasma concentration and poisoning rate of digoxin（P〈0. 05）. The plasma con- centration and poisoning rate of digoxin of the Bouyei nationality, the Miao nationality and the Shui nationality were reduced compared to the Han nationality. The plasma concentration and poisoning rate of digoxin of the female were increased compared to the male. CONCLUSION The plasma concentration of digoxin is impacted by many factors, including the compliance of the doctor＇s advice, physiological factors, pathological factors, and drug combination, etc, To carry out the plasma concentration de- tection is necessary for guaranteeing curative effect, reducing and correcting poisoning incidents.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2014年第8期639-642,共4页
Chinese Journal of Hospital Pharmacy
