摘要
使8只麻醉狗发生失血和组织胺性休克,然后给予回输血液及注射肾上腺素,分別记录血压、尿量及测定血浆血管紧张素Ⅱ(AⅡ)浓度.结果表明,在失血、回输血液及注射组胺时,动物AⅡ浓度与血压有着显著反相关变化,而给组胺性休克动物注射肾上腺素后,血压显著升高,AⅡ仅稍有下降,提示循环血量改变可能通过直接改变肾血流量来调节肾素释放,在循环血量减少吋,肾素-血管紧张素系统活性增强的机制,尽管包括儿茶酚胺的作用,伹主要是肾灌注压降低直接减少肾血流量所致.
The effects of shock induced by bloodletting or injecting histamine, blood-transfusion, and epinephrin on the renin-angiotensin system were studied in eight anesthetized dogs. The blood pressure, angiotensin Ⅱ (AⅡ) concentration in plasma and urine volume were determined respectively. When the fast hemorrhage or histamine were administered,the BP and urine volume rapidly dropped, then AⅢ significantly increased in all animals. Bloodtransfusing greatly decreased AⅡ in animals with hemorrhagic shock. and intravenous infusion of epinephrin a little decreased A Ⅱ in animals with histaminia.The experiments suggest that the direct stimulation of renal blood flow to renin-angiotengin system is a principal one,although there are many other regulating mechanisms, when the circulatory volume and blood pressure are decreasing.
出处
《贵阳医学院学报》
CAS
1991年第1期31-34,共4页
Journal of Guiyang Medical College
关键词
休克
失血
组胺
血管紧张素
shock
hemorrhage
histamine
angotonsin
