摘要
目的观察无创性肢体缺血预适应(noninvasive delayed limbischemic preconditioning,NDLIP)对急性脑梗死的疗效。方法选取40例急性脑梗死患者,随机分为NDLIP组和对照组,每组20例。其中NDLIP组于入院后在常规治疗基础上开始给予NDLIP——弹性绷带绑紧大腿根部,造成下肢短时间缺血。3次/d,5 min/次,间隔10 min。对照组不给予NDLIP,仅给予常规治疗。对所有病例均于治疗开始及治疗14 d后进行NIHSS评分、Barthel指数(BI)评分和Fugl-Meyer(FMA)总分评定。结果治疗前两组NIHSS评分、BI及FMA总分评分相近,差异无统计学意义(P>0.05)。治疗14 d后再次评定两组BI及FMA总分评分均有所提高及NIHSS评分明显降低,但NDLIP组患者提高幅度更大,经t检验两组差异有高度统计学意义(P<0.01)。结论 NDLIP治疗急性脑梗死可明显减轻临床神经功能缺损程度,提高脑梗死病人日常生活活动能力和肢体运动功能,比单纯常规治疗疗效好。NDLIP有望为脑梗死的临床治疗提供可行的、简便的、有效的治疗手段。
Objective To observe the curative effect of noninvasive delayed limb ischemic preconditioning （NDLIP） on the sufferers with acute cerebral infarction. Methods 40 cases with acute cerebral infarction were selected and randomly divided into NDLIP group and control group with 20 cases in each group.The sufferers in the NDLIP group, together with conventional therapy, were preconditioned by tightening the leg end arteries with NDLIP elastic bandage for 5 minutes per time and 3 times a day at an interval of 10 min.While the sufferers in the the control group had only conventional therapy with NDLIP.AI1 patients were provided routine treatment.All sufferers were assessed with the National Institutes of Health Stroke Scale（NIHSS）,the Barthel Index（BI） scores, and the Fugl-Meyer motor function scale（FMA） at the beginning of treatment and on the 14th day of treatment. Results The NIHSS, BI scores and the FMA were similar between the two groups before treatment without statistically significant differences （P 〉0.05）.There were remarkable differences between the two groups after 14 days of treatment, BI scores and the FMA increased, the NIHSS decreased in the two groups, while it increased more in the NDLIP group, and t-test showed the differences between the two groups were of high statistical significance（P〈0.01）.Conclusion NDLIP can alleviate the neurologic impairment in acute cerebral infarction treatment,enhance the activities of daily living and limb motor function.It is better than conventional treatment.NDLIP is expected to provide a feasible, simple and effective route for treating acute cerebral infarction.
出处
《中国疗养医学》
2014年第4期299-300,共2页
Chinese Journal of Convalescent Medicine
基金
973国家重点基础研究发展计划资助项目(2004CB720302)
