摘要
E-cadherin是维持上皮细胞极性和上皮完整性的重要分子,也是细胞上皮表型的主要标志.在肿瘤发生侵袭和转移的过程中上皮-间质转化(epithelial-mesenchymal transition,EMT)起了重要的作用,E-cadherin蛋白的表达缺失是EMT发生的主要标志.E-cadherin的异常表达对非小细胞肺癌的转移及患者的靶向治疗效果均有影响,就E-cadherin在非小细胞肺癌的转移和靶向治疗中的作用进行综述.
E-cadherin is a key molecule in maintaining cell polarity and epithelial integerity, and it is themain symbol of epithelial phenotype. The process of epithelial-mesenchymal transition （EMT） plays a critical role in the invasion and metastasis of tumor, while the deletion of E-cadherin protein expression is a defining characteristic of EMT. The abnormal expression of E-cadherin is associated with both metastasis and molecular targeted therap metastasis and y of patients with non-small ceil lung cancer. This review summarizes the relation of E-cadherin with molecular targeted therapy in non-small cell lung cancer.
出处
《昆明医科大学学报》
CAS
2014年第4期164-167,共4页
Journal of Kunming Medical University
基金
国家自然科学基金资助项目(81060189)
云南省自然科学基金资助项目(2010ZC107)
