摘要
目的探讨集束化治疗对脓毒性休克恒河猴脓的心肌结构损伤、血液动力学改变及意义.方法将12只恒河猴脓毒性休克动物模随机分对照组和实验组,每组6只,对照组只行基本生命体征支持,实验组行集束化治疗,分别测量治疗开始前、治疗后第1 h、第2 h、第3 h、第4 h、第5 h、第6 h的MAP及治疗6 h后的CVP、PAWP、CI、SVRI、PVR、LVWI、RWI.结果治疗6 h后的CVP、CI、RWI,2组比较差异有统计学意义(P<0.05);心肌损伤等级、PAWP、SVR、PVR、LVWI、2组差异无统计学意义(P>0.05),采用重复资料方差分析:MAP组内对比试验:不同疗程的MAP,差异无统计学意义(P>0.05);药物和疗程的交互作用差异无统计学意义(P>0.05),组间效应检验差异有较统计学意义(P<0.05).结论集束化治疗恒河猴6 h后可以阻止恒河猴的休克,但集束化治疗6 h后对脓毒性休克恒河猴的心肌无保护作用.
Objective To investigate the significance of bundle treatment in myocardial structure injury and hemodynamic changes on macaca rhesus with septic shock. Methods We divided 12 macaca rhesus with septic shock into two groups randomly, 6 in each group, and randomly selected a group as a control group, the other group as the experimental group.The control group was only given basic life support, experimental group was given bundle treatment, then we tested the MAP before starting treatment and after treatment for first hour, second hour, third hour, fourth hour, fifth hour and sixth hour, and tested the CVP, PAWP, CI, SVR, PVR, LVWI and RWI for six hours after treatment. Results The CVP, CI, RWI for six hours after treatment had statistical difference （P〈 0.05） ; the levels of myocardial structure injury, PAWP, SVR, PVR, LVWI had no statistical difference, （P〉0.05）, in repeated measures ANOVA： MAP within group comparison test： in different course had no statistical difference （P=0.06） , the interaction of drugs and course had no statistic difference （P=0.23） and effect test between two groups had statistic difference （P〈0.01） . Conclusion Bundle treatment for six hours can stop the macaca rhesus septic shock, but has no protective effects on myocardial cell of macaca rhesus septic shock.
出处
《昆明医科大学学报》
CAS
2014年第4期10-12,共3页
Journal of Kunming Medical University
基金
云南省科技厅内设研究机构基金资助项目(2010NS023)
