摘要
粗糙脉孢菌是一种重要的模式生物,在遗传调节机制、昼夜节律运行以及真菌光应答反应研究中起重要的作用.本综述主要介绍粗糙脉孢菌光受体WC-1和VVD的结构与功能,以及它们参与调节昼夜节律和光适应机制方面的研究进展.在该真菌中,所有已知的光应答反应都受蓝光调节,由光受体WC-1和VVD介导.WC-1是该真菌的转录因子,介导最初的光反应过程,产生VVD等多种光反应蛋白,而VVD通过负反馈机制抑制WC-1的转录作用.此外,vvd基因已经用于构建在哺乳动物中表达的光调节基因元件.
The filamentous fungus Neurospora crassa is an important model organism for studying genetic regulation, circadian rhythm and light response. This review summarized the structure and functions of WC-1 and VVD, and their participation in regulation of circadian rhythm and photoadaptation. All known light responses in Neurospora are regulated by blue light through two photoreceptors WC-1 and VVD. WC-1 is a transcription factor in this fungus and initiated the light response, generating a lot of light-responded proteins, such as VVD. VVD suppresses the transcription function of WC-lthrough negative feedback mechanism. In addition, the vvd gene has been applied to construct the photoresponsive elements of various genes in mammalian systems.
出处
《生物化学与生物物理进展》
SCIE
CAS
CSCD
北大核心
2014年第4期345-351,共7页
Progress In Biochemistry and Biophysics
基金
国家自然科学基金(81273553
30772284)
国家"重大新药创制"科技重大专项(2012ZX09301002-001-015)
教育部博士点基金(20121106110043)资助项目~~
关键词
粗糙脉孢菌
光受体
昼夜节律
光适应
Neurospora crassa, photoreceptor, circadian rhythm, photoadaptation
