期刊文献+

PI3K/Akt/mTOR信号通路在FCDⅡb型发病机制中的作用 被引量:2

Effect of PI3k/Akt/mTOR signaling pathway on development of focal cortical dysplasiaⅡb
原文传递
导出
摘要 局灶性大脑皮质发育不良(FCD)是一种局限性脑发育异常.占儿童及成人药物难治性癫痫病例数的40%。虽有文献显示手术切除FCD后的无发作率可达49%~70%,但仍有部分患者无法从中获益。因此,仍需针对病因研发新型的抗癫痫药物。在FCD的病理类型中,FCDⅡb型的病因学研究相对比较深入。
出处 《中华神经医学杂志》 CAS CSCD 北大核心 2014年第4期415-417,共3页 Chinese Journal of Neuromedicine
关键词 局灶性皮质发育不良Ⅱb型 P13K AKT MTOR信号通路 癫痫 Focal cortical dysplasia Ⅱb PI3k/Akt/mTOR signaling passway Epilepsy
  • 相关文献

参考文献15

  • 1Alexandre V, Walz R, Bianchin MM, et al. Seizure outcome after surgery for epilepsy due to focal cortical dysplastic lesions [J]. Seizure, 2006, 15(6): 420-427. 被引量:1
  • 2Ljungberg MC, Bhattacharjee MB, Lu Y, et al. Activation of mammalian target of rapamycin in cytomegalic neurons of human cortical dysplasia.AnnNeurol [J]. Ann Neurol, 2006, 60 (4): 420-429. 被引量:1
  • 3Blumcke I, Thom M, Aronica E, et al. The clinicopathologic spectrum of focal cortical dysplasias: a consensus classification proposed by an ad hoc Task Force of the ILAE Diagnostic Methods Commission[J]. Epilepsia, 2011, 52(1): 158-174. 被引量:1
  • 4Crino PB. Focal brain malformations: seizures, signaling, sequencing[J]. Epilepsia, 2009, 50(Suppl 9): 3-8. 被引量:1
  • 5Barkovich AJ, Guerrini R, Kuzniecky RI, et al. A developmental and genetic classification for malformations of cortical development: update 2012 [J]. Brain, 2012, 135(5): 1348-1369. 被引量:1
  • 6Moavero R, Cerminara C, Curatolo P. Epilepsy secondary to tuberous sclerosis: lessons learned and current challenges[J]. Childs Nerv Syst, 2010, 26(11): 1495-1504. 被引量:1
  • 7Feldman ME, Shokat KM. New inhibitors of the PI3K-Akt-mTOR pathway: insights into mTOR signaling from a new generation of Tor Kinase Domain Inhibitors (TORKinibs)[J]. Curr Top Microbiol lmmunol, 2010, 347: 241-262. 被引量:1
  • 8Becket A J, Urbach H, Scheffler B, et al. Focal cortical dysplasia of Taylor's balloon cell type: mutational analysis of the TSC1 gene indicates a pathogenic relationship to tuberous sclerosis [J]. Ann Neurol, 2002, 52(1): 29-37. 被引量:1
  • 9Grajkowska W, Kotulska K, Matyja E, et al. Expression oftuberin and hamartin in tuberous sclerosis complex-associated and sporadic cortical dysplasia of Taylor's balloon cell type [J]. Folia Neuropathol, 2008, 46(1): 43-48. 被引量:1
  • 10Gumbinger C, Rohsbach CB, Schulze-Bonhage A, et ah Focal cortical dysplasia: a genotype-phenotype analysis of polymorphisms and mutations in the TSC genes [J]. Epilepsia, 2009, 50(6): 1396-1408. 被引量:1

同被引文献25

引证文献2

二级引证文献9

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部