摘要
目的探讨血清胱抑素C(Cys C)水平与不同糖耐量患者颈动脉粥样硬化的相关性。方法选取糖耐量正常者(NGT组)30例、糖耐量异常患者(IGT组)60例、新诊断2型糖尿病患者(T2DM组)60例,检测3组受试者血生化指标及血清Cys C水平,用超声检测颈动脉内膜中层厚度(IMT)。结果 3组受试者血清Cys C水平及颈动脉IMT逐渐增高,组间两两比较差异有统计学意义(P<0.05)。多元Logistic回归分析显示,血清Cys C、高敏C反应蛋白(hs-CRP)、胰岛素抵抗指数(HOMA-IR)和低密度脂蛋白(LDL-C)是颈动脉粥样硬化的独立危险因素。结论糖代谢异常早期即存在高血清Cys C水平,并参与了糖尿病动脉硬化的进程。
Objective To investigate the changes of serum cystatin C levels in different glucose tolerance patients,as well as the correlation of these changes with carotid atherosclerosis. Methods 150 people were divided into 3 groups includ-ing normal glucose tolerance group （NGT group,n=30）,impaired glucose tolerance group （IGT group,n=60） and newly diag-nosed type 2 diabetes mellitus group （T2DM group,n=60）. Serum cystatin C,carotid intima-media thickness and other indicators were tested and analyzed. Results Serum cystatin C levels and carotid intima-media thickness were gradually increased in 3 groups,with significant differences between any two groups （P＆lt;0.05）. Multiple Logistic regression analysis showed that serum cystatin C,high sensitive C-reactive protein （hs-CRP）,HOMA-IR and LDL-C were independently associated with carotid atherosclerosis. Conclusion Cystatin C plays an important role in diabetic arteriosclerosis during its progression.
出处
《中国现代医药杂志》
2014年第3期13-15,共3页
Modern Medicine Journal of China
关键词
糖耐量异常
2型糖尿病
高敏C反应蛋白
颈动脉粥样硬化
胱抑素C
Impaired glucose tolerance
Type 2 diabetes mellitus
Cystatin C
High sensitive C-reactive protein
Carotid atherosclerosis
