摘要
目的 :碱性水解 4,4 二取代 2 苯基 2 口恶唑啉 5 酮 1。方法 :用超声波促进 1水解。结果 :1在超声波作用下很快水解 ,生成N 苯甲酰 2 ,2 二取代 2 氨基乙酸 ,没有超声辐照 ,室温水解需搅拌 2 4h ,而有超声辐照 ,反应仅需 15min。结论 :超声波能有效促进 1的碱性水解。
OBJECTIVE:To hydrolyze of 4,4 disubstituted 2 phenyl 2 oxazolin 5 one 1 in base.METHOD:Using ultrasonic irradiation to promote the hydrolysis of 1.RESULTS:1 hydrolyze very quickly with the presence of ultrasonic irradiation and N benzoyl α,α disubstituted glycines were obtained. In room temperature the reaction was completed within 15 min while it had to stir for 24 h without ultrasonic irradiation.CONCLUSION:Ultrasonic irradiation promotes hydrolysis of 1 in base effectively.
出处
《中国现代应用药学》
CAS
CSCD
北大核心
2001年第1期47-48,共2页
Chinese Journal of Modern Applied Pharmacy
