摘要
目的研究PTEN与非小细胞肺癌生存预后的关系。方法在肿瘤外科进行手术根治切除治疗的62例非小细胞肺癌患者的术后肿瘤标本和相应的14例癌旁组织标本用免疫组织化学(SP)法检测PTEN蛋白在非小细胞肺癌组织及癌旁组织的表达,并探讨其与患者生存期的关系。结果 PTEN表达癌及癌旁正常组织组间差异有统计学意义。PTEN阳性表达组与阴性表达组组间差异有统计学意义(P<0.05)。结论非小细胞肺癌组织中PTEN表达下调提示在非小细胞肺癌的发生过程中PTEN起了重要作用,PTEN低表达与生存期的缩短明显相关。
Objective To study the relationship between expression of PTEN and survival prognosis of NSCLC. Methods 62 cases with non-small cell lung cancer conducted radical surgical resection and 14 cases done adjacent normal tissue were selected and examined PTEN protein by immunohistochemical SP method to explore its relationship with the survival of the patients. Results The results indicated that there were statistically significant differences between PTEN expression of cancer and normal tissues adjacent groups. There were statistically signiifcant differences about the PTEN expression between the positive group and the negative group （P＆lt;0.05）. Conclusion The low expression of PTEN in non-small cell lung cancer shows that PTEN plays an important role in the development of non-small cell lung cancer, which is signiifcantly associated with the survival time of the patients.
出处
《医学研究与教育》
CAS
2014年第1期21-23,共3页
Medical Research and Education
关键词
非小细胞肺癌
免疫组织化学
PTEN
non-small-cell lung cancer
phosphatase and tensinhomology deleted on chromosome ten
immunohistochemistry
