摘要
目的 评估外周血淋巴细胞计数变化对于早期子宫颈癌手术后患者预后的预测价值.方法 2008年5月至2012年12月,收集123例接受开腹Ⅲ型广泛性子宫切除术、临床资料和随访资料完善的Ⅰ b1和Ⅱa1期子宫颈癌患者进行回顾性分析.患者年龄30 ～66岁,中位年龄43岁;随访5 ～61个月,中位随访时间为25个月,所有患者均在术前1周及术后第3、7天抽取静脉血检测血常规.分析淋巴细胞计数变化与预后的关系,影响预后的因素单因素分析采用log-rank检验,多因素分析采用Cox比例风险回归模型.结果 单因素分析结果显示,术前外周血低淋巴细胞计数（P=0.012）、淋巴结转移（P=0.001）和宫旁浸润（P =0.013）与早期子宫颈癌术后无进展生存率有关.多因素分析结果显示,术前低淋巴细胞计数[风险比（HR）为6.087,95％ CI为1.743 ～ 21.251,P=0.005]和淋巴结转移（HR=5.984,95％CI为1.803～19.802,P =0.003）是影响术后无进展生存率的独立危险因素.结论 外周血淋巴细胞计数对早期子宫颈癌术后患者的预后有一定的预测价值.
Objective To evaluate the clinical significance of changes in peripheral lymphocyte count after surgery in early cervical cancer.Methods The 123 patients with stage Ⅰ bl and Ⅱ al treated by abdominal type Ⅲ radical hysterectomy from May 2008 to December 2012 were reviewed.The median age of patients was 43 years old （range：30 to 66 years）.The median follow-up was 25 months with a range of 5-61 months.Peripheral blood samples were obtained on pre-operative,post-operation day 3 and 7.The log-rank test was used to compare the homogeneity of progression-free survival functions across strata defined by categories of prognostic variables.The Cox proportional hazard model was used to assess the significance of potential prognostic factors for progression-free survival.Results Univariate analyses preoperative lymphocyte count （P =0.012） and lymph nodes metastases status （P =0.001） and parametrial invasion （P =0.013） were significant risk factors for progression-free survival rate.On multivariate analyses,preoperative lymphocyte count [hazard ratio （HR） =6.087,95% CI：1.743-21.251,P =0.005] and lymph nodes metastases status （HR =5.984,95% CI：1.803-19.802,P =0.003） were independent risk factor of progression-free survival rate.Conclusion Peripheral lymphocyte counts after cervical cancer surgery may be a important prognostic factor.
出处
《中华妇产科杂志》
CAS
CSCD
北大核心
2014年第3期208-212,共5页
Chinese Journal of Obstetrics and Gynecology
关键词
宫颈肿瘤
妇科外科手术
淋巴细胞计数
预后
Uterine cervical neoplasms
Gynecologic surgical procedures
Lymphocyte count
Prognosis
