摘要
目的系统评价基于头孢菌素类或青霉素类幽门螺杆菌根除方案的有效性及安全性。方法计算机检索Pubmed、Embase等数据库,收集相关随机对照试验,终点指标为幽门螺杆菌根除率、不良反应发生率以及溃疡愈合率。共纳入5项研究,513名患者。结果基于头孢菌素类或青霉素类根除方案的有效性,两者差别无统计学意义(P>0.05)。药物不良反应发生率,头孢菌素组显著低于青霉素组(P<0.01);无严重不良反应发生。结论 2种方案有效性相似,但头孢菌素类较青霉素类不良反应发生率更低。
Objective To compare the relative efficacy and safety of cephalosporins or penicillins based H.pylori eradication regimen.Meth-ods Electronic databases were searched to identify the randomized con-trolled trials （ RCTs ） comparing cephalosporins and penecillins for H.pylori eradication.The outcome measure was H.pylori eradication rate , incidence of adverse drug reactions （ ADR） and ulcer healing.Five stud-ies including 513 patients were identified.Results No statistical differ-ence on H.pylori eradication efficacy between cephalosporins and peni-cillins based regimen was shown on Meta -analysis （ P＆gt;0.05 ）.No se-vere adverse drug reaction （ ADR） was reported in the identified studies , but the incidence of ADR of cephalosporins group was significantly lower than that of penicillin group （ P＆lt;0.01 ）.Conclusion The efficacy of cephalosporins is similar to penicillins for H.pylori eradication , but cephalosporins have shown a significantly lower incidence of ADR.
出处
《中国临床药理学杂志》
CAS
CSCD
北大核心
2014年第4期350-353,共4页
The Chinese Journal of Clinical Pharmacology
