摘要
通过对 N1- (2 -呋喃烷基 ) - N3- (羟烷基 ) - 5-氟脲嘧啶的氧化以及与 O,O-二乙基硫代亚磷酸酯的加成反应合成了新型 N1- (2 -呋喃烷基 ) - 5-氟脲嘧啶的 α-羟基硫代膦酸酯衍生物 ,进一步以间氯过氧苯甲酸氧化得到相应的 α-羟基膦酸酯衍生物。
Several[WT5BX] N^1-(2-furanidyl)-5-fluorouracil derivatives of α-hydroxythiophosphonate were synthesized [WT5BX]via oxidation of N^1-(2-furanidyl)-N^3-(hydroxyalkyl)-5-fluorouracil, followed by addition with O,O-diethyl thiophosphite. The phosphonate products were obtained by oxidation with meta-chloro peroxybenzoic acid(MCPBA) from corresponding thiophosphonates.
出处
《合成化学》
CAS
CSCD
2001年第1期1-2,共2页
Chinese Journal of Synthetic Chemistry
