摘要
基于在盐酸介质中，利用甲氧氯普胺－亚硝酸钠－α－萘胺的重氯化－偶合反应，建立了流动注射光度法测定甲氧氯普胺的新方法。利用单纯形优化法选择了最佳实验条件。方法的线性范围为０．０～３０ｍｇ／Ｌ，进样频率为１６０／ｈ。１１次重复测定的相对标准偏差小于０．６％，该方法已成功用于药物中甲氧氯普胺含量的测定，测定结果与药典法对照，并经统计学处理，结果满意。
A rapid and sensitive flow-injection spectrophotometric method was proposed for the determination of metoclopramide. This method was based on the diazotisation of metoclopramide with sodium nitrite in acidic medium and coupling with alpha -naphthylamine. The optimal experimental condition was obtained by using the simplex optimization method. The linear range was 0.0 similar to 30 mg/L, and the sample throughput was 160 samples h(-1). The relative standard deviation of eleven replicate measurements was less than 0.6%. The method was used to determine metoclopramide in tablets and injections. The results were statistically compared with those obtained by pharmscopoeia method.
出处
《分析化学》
SCIE
EI
CAS
CSCD
北大核心
2001年第2期216-218,共3页
Chinese Journal of Analytical Chemistry
