摘要
目的:观察蒙药冬青叶-7胶囊的镇咳、祛痰、抗炎作用;研究蒙药冬青叶-7胶囊对小鼠急性毒性作用。方法:采用小鼠氨水引咳法、气管酚红排痰法和二甲苯致小鼠耳肿胀法评价蒙药冬青叶-7胶囊的镇咳、祛痰、抗炎作用;采用典型的急性毒性试验方法,研究蒙药冬青叶-7胶囊对小鼠的急性毒性作用。结果:蒙药冬青叶-7胶囊各组与空白对照组比较咳嗽次数明显少(P<0.05),首次咳嗽发生明显延迟P<0.05,明显增加小鼠呼吸道黏膜酚红的排出量P<0.05,并显著抑制小鼠耳廓肿胀度P<0.05;小鼠全部存活,未测出LD50,最大给药量为临床上成人日用剂量的133倍。结论:蒙药冬青叶-7胶囊具有明显的镇咳、祛痰、抗炎作用;蒙药冬青叶-7胶囊在本实验条件下未发现急性毒性反应,为临床安全应用提供了实验依据。
Purpose： 1. Observe the Mongolian Medicine Dongqingye -7 capsule＇s relieving cough, expectorant and anti- inflam matory function. 2. By mice acute toxicity test research the safe clinical usage of Mongolian Medicine Dongqingye - 7 capsule. Methods ： 1. Using ammonia cough induction method, phenol red expectoration method and xylene ear edema method evaluate Mon- golian Medicine Dongqingye - 7 capsule＇s relieving cough, expectorant and anti - inflammatory effects. 2. Acute toxicity test was ac ted to determine the safe clinical usage of Dongqingye - 7 capsule. Results ： 1. The cough frequency of Dongqingye - 7 capsule were lower than model group （ P 〈 0.05）, first cough was later significantly （P 〈 0.05 ）, increase respiratory mucosa in mice phenol red excretion P 〈 0.05, and significantly inhibited mouse ear swelling P 〈 0.05. 2. All mice were survived, The LDs0 was failed to de tect, the maximum dose was 133 times more than clinical adult dosage. Conclusions： 1. The Mongolian Medicine Dongqingye -7 capsule had pharmacological effects as relieving cough, expectorant and anti - inflammation. 2. Provided experimental evidence to ensure safe usage in clinical.
出处
《中国民族医药杂志》
2014年第3期52-54,共3页
Journal of Medicine and Pharmacy of Chinese Minorities
