摘要
目的了解胆石症合并胆道感染患者病原菌分布与临床特征的关系,以期能为治疗提供参考。方法选取2012年1月-12月医院胆石症合并胆道感染120例患者为研究对象,术中取得胆汁进行病原菌培养及药物敏感试验检查,并分析与临床特征间的关系,数据采用SPSS 17.0软件进行统计分析。结果 120例患者取得的胆汁标本中病原菌培养阳性者97例,培养阳性率80.83%,共培养出病原菌112株,其中革兰阴性菌93株,占83.04%;革兰阴性菌及革兰阳性菌均对临床常用的抗菌药物存在一定的耐药性;患者年龄≥60岁、有食用生鱼史、胆道手术史、肝病史时胆汁病原菌培养阳性分别占50.52%、59.79%、70.10%、67.01%,差异有统计学意义(P<0.05)。结论胆石症合并胆道感染时胆汁感染病原菌以革兰阴性菌为主,主要为大肠埃希菌、肺炎克雷伯菌、铜绿假单胞菌及肠球菌属,对临床常用抗菌药物均有一定耐药性,胆道感染与食用鱼生史、胆道手术史及肝炎病史存在一定关系。
OBJECTIVE To investigate the relationship between pathogens distribution of patients with cholelithiasis and biliary tract infection and their clinical characteristics so as to provide reference for treatment. METHODS A total of 120 patients with cholelithiasis and biliary tract infection were selected for this study from Jan to Feb in 2012. Their bile was obtained during operation for pathogens culture and drug susceptibility testing, with analysis on its relationship between clinical characteristics. All the data were statistically analyzed by SPSS17.0 software. RESULTS A total of 97 cases out of the 120 bile samples obtained from patients showed culture-positive patho- gens, the culture positive rate reached 80.83%. In the 112 cultured strains, 93 strains of gram-negative bacteria accounted for 83.04%. Both gram-negative bacteria and gram-positive bacteria showed certain drug-resistance to commonly used clinical antimicrobials. The positive rate of bile pathogens culture among patients more than 60 years old was 50.51%;for patients who had a history of sashimi consumption, biliary tract operation and hepati- tis, the same figure went to 50.52%, 59.79%, 70.10% and 67.01% respectively. The difference was significant （P〈0.05）. CONCLUSION For patients with eholelithiasis and biliary tract infection, gram-negative bacteria occu- pies the first place in bile infected by pathogens, mainly as Escherichia coli, Klebsiella pneumoniae, Pseudornonas aeruginosa and Enterococcus, all of which showed certain drug resistance to commonly used clinical antimicrobials. Meanwhile, biliary tract infections are proved to be associated with the history of sashimi consumption, biliary tract operation and hepatitis.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2014年第8期2001-2003,共3页
Chinese Journal of Nosocomiology
基金
浙江省科技厅科技局基金资助项目(2007c33006)
关键词
胆石症
胆道感染
临床特征
耐药性
Cholelithiasis
Biliary tract infection
Clinical characteristics, Drug resistance
