摘要
目的:探讨参附注射液致不良反应(ADR)的一般规律和药物流行病学特点,为临床合理用药提供参考。方法:检索1995-2013年发表的中文医药学期刊,收集参附注射液致ADR病例130例,应用统计学方法对相关信息进行回顾性分析。结果:参附注射液致ADR与患者性别、年龄无显著相关性;给药剂量越大、联合用药越多,越易发生ADR;用药30 min内ADR发生比例明显较高;临床表现复杂多样,涉及人体多器官、多系统,以一般过敏反应为主,但需警惕过敏性休克和严重心血管事件。结论:坚持辨证施治、规范用药,注重患者个体差异、增强防范意识,强化用药监护可有效降低参附注射液ADR的发生率。
OBJECTIVE： To investigate the regularity and pharmacoepidemiology characteristics of ADR induced by Shenfu in-jection, and to provide reference for rational drug use in the clinic. METHODS： Retrieved from Chinese medical journals periodi-cals during 1995-2013, 130 cases of ADR induced by Shenfu injection were collected and analyzed retrospectively by statistic methods. RESULTS ： There was no significant correlation between ADR induced by Shenfu injection and patient＇ s gender and age; larger drug dosage and more drug combination was, more easily ADR occurred. Most of ADR cases occurred within 30 rain. Multi- ple organs and systems were involved, and clinical manifestation was mainly general allergic reaction; but anaphylactic shock and serious cardiovascular events need to be bewared of. CONCLUSIONS： It is suggested to insist on treatment based on syndrome dif-ferentiation and standard medication, pay attention to individual differences, increase awareness of prevention and strengthen super-vision so as to effectively reduce the incidence of ADR induced by Shenfu injection.
出处
《中国药房》
CAS
CSCD
2014年第16期1496-1498,共3页
China Pharmacy
