摘要
人类内源性病毒包括人类反转录病毒与博尔纳病病毒与精神心理疾病的关系尚不明确。作为人类基因组的组成成分,人类内源性病毒可能是精神分裂症患者遗传、环境、免疫因素的联结点。本文从人类内源性病毒在精神分裂症中的临床与实验室证据与可能的致病机制进行综述,以揭示人类内源性病毒在精神分裂症病因学与致病机制中的作用。
Abstract：The association between psychogenic illness and human endogenous viruses （HEVs）, including human endogenous retrovirus and Borna disease virus, remains unclear. As the component of human genome, HEVs may become the joint of various pathogenic factors of schizophrenia （SZ）, such as heredity, environment, and immunity. In this review, we strive to uncover the clinical and laboratory evidence for the roles and possible pathogenic mechanism of HEVs in the development of SZ.
出处
《病毒学报》
CAS
CSCD
北大核心
2014年第1期98-102,共5页
Chinese Journal of Virology
基金
国家自然科学基金项目(81000763)
关键词
人类内源性病毒
精神分裂症
致病机制
Key words. Human endogenous virus
Schizophrenia
Pathogenic mechanism
