摘要
嗅觉介导素4(OLFM4)是一种新的分泌型糖蛋白,是嗅觉介导素家族的重要成员之一,主要表达于人类骨髓、胃、小肠、结肠、胰腺及前列腺等组织。对维护细胞多种生物学功能的稳定具有重要的作用,包括神经的发生、神经嵴形成和细胞间黏附、细胞周期的调节及细胞凋亡等。OLFM4表达异常与多个组织器官的肿瘤发生有一定的关系,如乳腺癌、肺癌、胰腺癌、胃癌及结直肠癌等,且OLFM4表达状况与肿瘤的进展及肿瘤患者的预后密切相关。
Olfactomedin 4（OLFM4）,a new secreted glycoprotein,is an important member of the family of olfactomedin.OLFM4 mainly expresses in human bone marrow,stomach,small in-testine,colon,pancreas,prostate and other tissues.It plays an important role in maintaining the stability of various biological functions,including neural occurrence,neural crest formation,inter-cellular adhesion,cell cycle regulation and apoptosis.The abnormal expression of OLFM4 is cor-related with the tumorigenesis,including breast cancer,lung cancer,pancreatic cancer,gastric cancer,colorectal cancer,etc.Moreover,the expression of OLFM4 is closely associated with tumor progression and prognosis.
出处
《南昌大学学报（医学版）》
CAS
2014年第1期92-96,共5页
Journal of Nanchang University：Medical Sciences
