摘要
目的 探讨多囊卵巢综合征(PCOS)患者尿酸与胰岛素抵抗(IR)的关系.方法 选取2012年6月-2013年6月就诊于厦门大学附属第一医院生殖科门诊的65例PCOS患者为研究对象,按照胰岛素抵抗指数(HOMA-IR)分为IR组41例和非胰岛素抵抗(NIR)组24例.分别于月经周期第2~4天上午空腹抽取肘静脉血,测定黄体生成素(LH)、卵泡刺激素(FSH)、睾酮、空腹胰岛素(FINS)、空腹血糖(FBG)、三酰甘油(TG)、胆固醇(TC)、尿酸(UA)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)水平,并计算体质指数(BMI),比较两组各项指标.结果 IR组BMI及FBG、FINS、UA水平高于NIR组(P<0.05);BMI、FINS、FBG、UA与HOMA-IR呈正相关(r值分别为0.48、0.95、0.25、0.42,P<0.05).结论 UA与 IR 关系密切,二者在PCOS患者代谢综合征的发生、发展中共同起促进作用.
Objective To explore the relationship between uric acid (UA) and insulin resistance (IR) in patients with Polyeystie ovary syndrome (PCOS). Methods Sixty -five PCOS patients admitted to this hospital from June 2012 to June 2013 were divided, according to insulin resistance index (HOMA -IR), into groups IR (n = 41 ), non -IR (n = 24). Fast- ing venous blood was drawn on days 2 ~ 4 of menstrual cycle to determine the levels of luteinizing hormone ( LH), follicle stimu- lating hormone ( FSH), testosterone ( T), fasting insulin ( FINS), fasting blood glucose ( FBG), triglyeeride ( TG), cho- lesterol (TC), low density lipoprotein (LDL), and calculate BMI. The above indexes were compared between 2 groups. Re- sults BMI, and levels of FPG, FINS, UA were higher in IR group than in non - IR group (P 〈 0. 05). BMI, FINS, FPG, UA were positively with HOMA - IR ( r = 0.48, 0. 95, 0.25, 0. 42, respectively, P 〈 0.05 ). Conclusion UA is closely related with IR, both play a promotive role in occurrence and development of metabolic syndrome in PCOS patients.
出处
《中国全科医学》
CAS
CSCD
北大核心
2014年第5期586-587,共2页
Chinese General Practice
关键词
多囊卵巢综合征
尿酸
代谢综合征X
胰岛素抵抗
Polycystie ovary syndrome
Uric acid
Metabolic syndrome X
Insulin resistance