摘要
目的:探讨布地奈德治疗中重度支气管哮喘急性发作患儿的效果及对肺功能的影响。方法:将本院2008年1月—2012年12月期间收治的60例中重度支气管哮喘急性发作患儿随机等分为对照组和观察组,均给予0.5%沙丁胺醇(150μg·kg-1)+0.025%溴化异丙托品(1ml)雾化液吸入治疗,仅观察组加用0.05%布地奈德(2ml);分析2组的临床有效率,治疗前、2h后的临床积分、常规指标(心率、呼吸次数及血氧饱和度SaO2)及肺功能指标(肺活量、第一秒用力呼吸容积FEV1、FEV1占预计值百分比及FEV1占用力肺活量百分比),同时采用Logistic多元回归分析影响治疗效果的因素。结果:观察组的临床控制(36.67%vs.10.00%,P<0.05)和总有效率(96.67%vs.80.00%,P<0.05)均高于对照组,且无效率低于对照组(3.33%vs.20.00%,P<0.05);观察组治疗2h后的临床积分、呼吸次数、血氧饱和度SaO2及肺功能均优于对照组(P<0.05)。病程、治疗前FEV1%、FEV1变异率、治疗前临床评分、PaO2和治疗方案均是影响疗效的因素。结论:布地奈德治疗中重度支气管哮喘急性发作患儿的效果较好,可改善临床积分及肺功能指标,同时鉴于治疗方案是影响治疗效果的因素,因此针对此类患儿应及时给予布地奈德治疗。
OBJECTIVE To explore the clinical effects of budesonide on symptoms and pulmonary functions in children with moderate to severe acute bronchial asthma. METHODS Sixty children with moderate to severe acute bronchial asthma from Jan. 2008 to Dec. 2012 in our hospital were randomly assigned into control group and observation group （n = 30）. All patients received inhalation therapy of 150μg·k^-1 0. 5 %salbutamol and 1 ml 0. 025 % ipratropium bromide,while only the observation group was given 2 mL 0. 05% budesonide additionally. The clinical efficacy, clinical integration, conventional indicators （heart rate, respiratory rate and oxygen saturation SaO2 ） and pulmonary functions （vital capacity, forced expiratory volume in one sec- ond FEV1 , FEV1 occupied by predicted value and force vital capacity） before and at 2nd h after treatment were investigated in both groups. The logistic regression analysis was used to analyze the factors affecting treatment. RFNULTS The clinical con- trol rate （36. 67 % vs. 10. 00 %, P〈0. 05） and total efficiency （96. 67 % vs. 80. 00 %, P〈0. 05） of observation group were high- er than the control group. The observation group＇s clinical integration, respiratory rate, SaO2 and pulmonary functions were su- perior to control group at 2nd h after treatment （P〈0. 05）. The duration, FEV1 % before treatment, FEV1 mutation rate, PaO2, clinical integration before treatment and the treatment options were the factors influencing efficacy. CONCLUSION The clinical effects of budesonide on symptoms and pulmonary functions in children with moderate to severe acute asthma were bet- ter with improved clinical integration and pulmonary functions.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2014年第7期565-568,共4页
Chinese Journal of Hospital Pharmacy
