摘要
目的探讨乙肝病毒携带者(ASC)外周血单核细胞(PBMCs)中Toll样受体2(TLR2)的表达水平。方法选取40例ASC和健康志愿者20例为研究对象,分为乙肝病毒(HBV)复制不活跃组、HBV复制活跃组和健康组,分析各组患者的PBMCs中TLR2及血清中肿瘤坏死因子(TNF-α)水平。结果 HBV复制活跃组的TLR2阳性细胞百分比和TLR2平均灰度比值均高于健康组,差异具有统计学意义(P<0.05);HBV复制不活跃组与健康组比较则差异不明显。HBV复制活跃组、HBV复制不活跃组的TNF-α水平均高于健康组,差异均有统计学意义(P<0.05);HBV复制活跃组TNF-α水平高于HBV复制不活跃组,差异具有统计学意义(P<0.05)。结论ASC外周血单核细胞TLR2的表达水平高于健康人群,且与HBV的增殖存在一定的相关性。
Objective To investigate the expression of Toll-like receptors 2 （TLR2） in peripheral blood mono- nuclear cells （PBMCs） of hepatitis B virus （HBV） carriers （ASC）. Method 40 cases of ASC and 20 cases of healthy volunteers were divided into inactive HBV replication group, active HBV replication group and healthy group to analyze the levels of TLR2 in PBMCs and tumor necrosis factor （TNF-a） in the serums. Results The percentage of positiveTLR2 cells and the ratio of TLR2 average grey degree in the active HBV replication group were higher than the healthy group and the differences were statistically significant （P〈 0.05） ; the differences between the inactive HBV replication group and the healthy group was insignificant. The levels of TNF-a in both the active and inactive HBV replication groups were higher than the healthy group and the differences were statistically significant （P〈0.05） ; the level of TNF-ain the active HBV replication group was higher than that of the inactive HBV replication group and the difference was statistically significant （P〈0.05）. Conclusion The expression of TLR2 in PBMCs of hepatitis B virus carriers is higher than the healthy people and there is a certain correlation between the expression of TLR2 and the proliferation of HBV.
出处
《保健医学研究与实践》
2014年第2期62-63,共2页
Health Medicine Research and Practice
