摘要
目的研究E-钙黏附蛋白(E-cad)和γ-连环蛋白(γ-cat)在大肠癌组织中的表达与大肠癌侵袭转移的关系。方法应用免疫组织化学二步法检测52例大肠癌组织及20例癌旁正常组织中E-cad和γ-cat的表达。结果 大肠癌组织中E-cad和γ-cat的阳性表达率均显著低于癌旁正常组织(P<0.05)。E-cad的表达与大肠癌的分化程度、临床分期、淋巴结转移、浸润深度及是否有远处器官转移密切相关(P<0.05),γ-cat的表达与大肠癌的分化程度、淋巴结转移及远处转移密切相关。大肠癌组织中E-cad和γ-cat两者的表达呈正相关(P<0.05)。结论 E-cad,γ-cat的表达在大肠癌浸润及侵袭转移的过程中起着重要作用,检测两者的表达对大肠癌的诊断、治疗及判断预后有着重要的临床意义。
Objective To study the expression of E-cadherin （ E-cad ） and γ-catenin（γ-cat） in human colo- rectal carcinoma, and the relationship of their expression with the invasion and metastasis of human colorectal carcinoma. Methods The PV Immunohistochemistry method was used to detect the expression of E-cad and γ-cat in 52 cases of colorectal carcinoma and 20 cases of adjacent normal colorectal tissue. Results The expression of E-cad and γ-cat in colorectal carcinoma was significantly lower than that in adjacent normal tissue （ P 〈 0.05 ）. The expression of E-cad was closely related with the differentiatial degree, clinical stage, lymphoid metastases, depth of tumor invasion and distant or- gan metastasis of colorectal carcinoma,and the expression of γ-cat was no significant correlation in depth of tumor inva- sion. The expression of E-cad and γ-cat in colorectal cancer was positively correlated （ P 〈 O. 05 ）. Conclusion The ex- pression of E-cad and γ-cat plays an important role in progression, invasion and metastasis of colorectal carcinoma, and the detection of them has important clinical significance for diagnosis, treatment and prognosis of colorectal carcinoma.
出处
《潍坊医学院学报》
2014年第1期48-50,共3页
Acta Academiae Medicinae Weifang
