摘要
研究了小鼠黑色素瘤细胞B16、骨髓瘤细胞SP2 / 0和小鼠正常成纤维细胞ME对99Tcm MIBI和99Tcm tetrofosmin的摄取情况。结果表明 ,小鼠黑色素瘤细胞B16、骨髓瘤细胞SP2 / 0对99Tcm MIBI的摄取量高于99Tcm tetrofosmin ;小鼠正常成纤维细胞ME对99Tcm MIBI和99Tcm tetrofosmin的摄取量都很低。研究了99Tcm MIBI和99Tcm
The cellular uptake of 99 Tc m MIBI and 99 Tc m tetrofosmin in murine melanoma cell line B16,murine myeloma cell line SP2/0 and normal fibroblast line ME are studied.The results show that the uptake in tumor cells is remarkably higher than in normal cells.The biodistribution of 99 Tc m MIBI and 99 Tc m tetrofosmin in tumor bearing mice are also studied. Although the tumor to blood concentration ratios are fairly high,the overall target specificity is low.
出处
《核化学与放射化学》
EI
CAS
CSCD
北大核心
2000年第4期214-219,237,共7页
Journal of Nuclear and Radiochemistry
基金
国家自然科学基金资助项目! (2 97310 2 0 0 2 )
关键词
肿瘤
诊断
心肌显像剂
摄取
锝放射性标记物
肿
Tc m MIBI
99 Tc m tetrofosmin
murine carcinoma cell lines
tumor bearing mice
